职称 教授
学位 博士
政治面貌 中共党员
电话 027-87618028
邮箱 sbcao@mail.hzau.edu.cn
研究方向 媒介病毒免疫与致病机制及防控技术
教育经历
1994.09-1998.07,华中农业大学,农学学士
1999.09-2005.07,华中农业大学,农学硕士/博士
主要职历
1998.07-2006.12,华中农业大学动物医学院,助教、讲师
2006.10-2005.08,夏威夷大学(美国),访问学者/博士后
2007.01-2011.12,华中农业大学动物医学院,副教授
2012.01-现在,华中农业大学动物医学院,教授
科研成果
科研方向
主要从事乙型脑炎病毒、西尼罗河病毒、寨卡病毒等媒介传播病毒的传播、免疫、致病机制及防控技术研究。主要科研方向包括:(1)媒介病毒的传播机制;(2)媒介病毒的免疫损伤与致病机制;(3)媒介病毒防控技术产品研发。
学术成绩
长期专注于乙型脑炎病毒、西尼罗河热等媒介病毒研究,主持承担国家重点研发计划、国家自然科学基金等课题10项。近5年以通讯作者在Science Signaling、Journal of Immunology、Journal of Virology、Journal of Infectious Diseases等领域期刊发表SCI论文20余篇,获得湖北省科技进步一等奖1项、新兽药注册证书1项。
主持科研项目
1. 国家重点研发计划-重要神经嗜性人兽共患病免疫与致病机制研究(2016YFD0500400),2016/06-2020/12,4900万元
2. 国家自然科学基金杰出青年基金,动物传染病学(31825025),2019/01-2023/12,400万元
3. 湖北省自然科学基金创新群体项目,神经嗜性人兽共患病(2019CFA010),2019/01-2021/12,50万元
代表性学术论文
1. Bohan Zheng, Xugang Wang, Yixin Liu, Yunchuan Li, Siwen Long, Changqin Gu, Jing Ye, Shengsong Xie, Shengbo Cao*. Japanese Encephalitis Virus infection induces inflammation of swine testis through RIG-I-NF-ĸB signaling pathway. Veteriary Microbiology, 2019, 238:108430.
2. Shaomei Huang, Jiangjiang Gu*, JingYe, Bin Fang, Shengfeng Wan, Caoyu Wang, Usama Ashraf, Qi Li, Xugang Wang, Lin Shao,Yunfeng Song, Xinsheng Zheng, Feifei Cao, Shengbo Cao*. Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity. Journal of Colloid and Interface Science, 2019, 542: 198–206.
3. Zheng Chen, Xugang Wang, Bohan Zheng, Jing Ye*, Awais Anees, Dengyuan Zhou, Hao Zhang, Yunfeng Song, Huanchun Chen, Shuhong Zhao, Shengbo Cao*. Activation of N-Methyl-D-Aspartate Receptor on Neurons Plays pivotal Role in JEV-induced Neuronal Damage. Journal of Neuroinflammation. 2018,15(1):238.
4. Yunchuan Li#, Hao Zhang#, Bibo Zhu, Usama Ashraf, Zheng Chen, Qiuping Xu, Dengyuan Zhou, Bohan Zheng, Yunfeng Song, Huanchun Chen, Jing Ye*, and Shengbo Cao*. Microarray Analysis Identifies the Potential Role of Long Non-Coding RNA in Regulating Neuroinflammation during Japanese Encephalitis Virus Infection. Frontiers in Immunology. 2017,8:1237.
5. Jing Ye, Zheng Chen, Yunchuan Li, Zikai Zhao, Wen He, Ali Zohaib, Yunfeng Song, Chenglin Deng, Bo Zhang, Huanchun Chen, Shengbo Cao*. Japanese Encephalitis Virus NS5 Inhibits the Type I Interferon Production by Blocking the Nuclear Translocation of IRF3 and NF-κB. Journal of Virology,2017, 91(8): e00039-17.
6. Jing Ye, Hao Zhang, Wen He, Bibo Zhu, Dengyuan Zhou, Zheng Chen, Usama Ashraf, Yanming Wei, Ziduo Liu, Zhen F. Fu, Huanchun Chen, Shengbo Cao*.Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus.Science Signaling, 2016,9(448):ra98.
7. Usama Ashraf , Bibo Zhu, Jing Ye, Shengfeng Wan, Yanru Nie, Zheng Chen, Xiaodong Duan , Hao Zhang, Huanchun Chen, Shengbo Cao*. microRNA-19b-3p modulates Japanese encephalitis virus-mediated inflammation via targeting RNF11.Journal of Virology,2016, 90(9):4780-95.
8. Zheng Chen#, Jing Ye, Usama Ashraf, Yunchuan Li, Siqi Wei, Shengfeng Wan, Ali Zohaib,Yunfeng Song, Huanchun Chen, Shengbo Cao*. miR-33a-5p modulates Japanese Encephalitis Virus Replication by targeting Eukaryotic Translation Elongation Factor 1A1. Journal of Virology, 2016,90(7):3722-3734.
9. Bibo Zhu, Jing Ye, Yanru Nie, Usama Ashraf,, Ali Zohaib, Xiaodong Duan, Zhen F. Fu, Yunfeng Song, Huanchun Chen, Shengbo Cao *. MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125. Journal of Immunology 2015,195(5):2251-62.
10. Jing Ye#, Rong Jiang#, Min Cui, Bibo Zhu, Leqiang Sun, Yueyun Wang, Ali Zohaib, Qian Dong, Xindi Ruan, Yunfeng Song, Wen He, Huanchun Chen, Shengbo Cao*. Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis. Journal of Infectious Diseases.2014, 15;210(6):875-89.
授权发明专利
1.曹胜波,梅丽,李么明,陈龙,邵林,朱碧波,吴兵,陈焕春. 一种用于猪、人和蚊子中乙型脑炎病毒抗原检测的ELISA试剂盒及应用. 中国发明专利, ZL201010549519.7
2.曹胜波,朱碧波,刘学芹,徐敏,叶静,杨晓红,陈龙,陈焕春. 预防西尼罗河病毒的重组假型杆状病毒Bac-G-prM/E及疫苗与应用. 中国发明专利, ZL 201110314717.X
备注
入选国家百千万人才工程-有突出贡献中青年专家,获得国家杰出青年基金。2014年获华中农业大学优秀班主任;2016年获华中农业大学师德先进个人。