职称 教授

学位 博士

政治面貌 中共党员

电话 027-87281810

邮箱 zhaojunlong@mail.hzau.edu.cn

研究方向 寄生虫学与动物疾病防控

教育经历

1982 09—1987 06 华中农业大学兽医专业（五年制）学习，获学士学位。

1987 09—1990 06 华中农业大学硕士研究生，获硕士学位。

1997 09—2001 06 华中农业大学博士研究生，获博士学位。

主要职历

1990 07—1992 12 华中农业大学畜牧兽医学院 助教

1993 01—1997 10 华中农业大学畜牧兽医学院 讲师

1997 11—2001 12 华中农业大学畜牧兽医学院 副教授

2002 01— 华中农业大学畜牧兽医学院 教授

2003 02—2010 12 华中农业大学动物科技学院、动物医学院副院长

2011 01—2017 04 华中农业大学动物科技学院、动物医学院院长

2003 02—农业微生物学国家重点实验室固定研究人员

2003 04—10 德国Goettingen大学兽医研究所访问学者

2006 10—2007 04 澳大利亚蜱热病研究中心高级访问学者

科研成果

科研方向

  动物寄生虫病的病原学、流行病学、致病机制以及畜禽规模化养殖的疾病控制。

学术成绩

  主要从事动物寄生虫学的科研以及畜禽规模化养殖的疾病控制等工作，研究方向为病原分子生物学与基因工程，研究重点在血液原虫病和人兽共患病（如巴贝斯虫、弓形虫、附红细胞体）等。先后主持国家自然科学基金、国际科学基金、863计划、973计划、教育部新世纪优秀人才支持计划、农业行业公益性项目、教育部重点科研项目、湖北省自然科学基金、湖北省科技攻关等各类课题20余项。在国内外发表论文220余篇（SCI收录97篇），出版专著（教材）10部，其中主编一部、副主编三部，获国家专利5项，鉴定成果3项，获湖北省科技进步一等奖1项、二等奖2项、三等奖2项。

主持的主要科研项目

（1）国家自然科学基金重点项目： 东方巴贝斯虫对宿主特异性致病的差异机制研究（31930108 , 2020-2024）；

（2）国家自然科学基金：弓形虫顶质体中丙酮酸的代谢机制研究（31872463 ,2019-2022）

（3）973计划：牛羊重要寄生虫病致病的分子基础（2015CB150302，2015-2019）；

（4）湖北省自然科学基金创新团队（2017CFA020，2017-2019）

（5）国家自然科学基金运输应激影响弓形虫速殖子与缓殖子转化的分子机制（31372429，2014-2017）；

（6）第七批中国南非政府间合作项目：宏基因组方法鉴定中国和南非野生动物及宠物蜱传性寄生虫及分子特性研究（2014-2017）

（7）863计划：土壤环境动物源传染性病原菌污染控制与修复技术研究（2009AA06Z302；2009-2012）；

（8）国家自然科学基金：水牛源泰勒虫未定种的分类学及流行病学研究（30972175；2010-2012）；

（9）农业行业公益性计划：日本血吸虫病、包虫病、弓形虫病、附红细胞体病等重要人畜共患寄生虫病的防控技术研究（200903036；2009-2013）；

（10）国家自然科学基金：东方巴贝斯虫棒状体相关蛋白1的基因克隆与功能研究（30671575；2007-2009）；

（11）教育部新世纪优秀人才支持计划：东方巴贝斯虫入侵相关蛋白研究（NCET06-0668；2007-2009）；

（12）高等学校博士学科点专项科研基金（优先发展领域）弓形虫与宿主细胞黏附的分子机制。（20110146130001，2012-2014）

 

代表性学术论文

1. Jiaying Guo, Yali Sun, Xiaoying Luo, Muxiao Li, Pei He, Lan He*,Junlong Zhao*. De novo transcriptome sequencing and comparative analysis of Haemaphysalis flava Neumann, 1897 at larvae and nymph stages .Infection, Genetics and Evolution Volume 75, November 2019, 104008

2. Long Yu，Zhou Shen，Qin Liu，Xueyan Zhan, Xiaoyin Luo,Xiaomeng An,Yali Sun,Muxiao Li,Sen Wang,Zheng Nie,Yangsiqi Ao,Yangnan Zhao,Guiqing Peng,Choukri Ben Mamoun,Lan He*,Junlong Zhao.Crystal structures of Babesia microti lactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis. FASEB journal : 2019-Oct-04 (Epub 2019 Oct 04)10.1096/fj.201901259R 

3. Xueyan Zhan, Junwei He, Long Yu, Qin Liu,Yali Sun, Zheng Nie, Jiaying Guo, Yangnan Zhao, Muxiao Li, Xiaoying Luo,Lan He Junlong Zhao*. Identification of a novel thrombospondin-related anonymous protein (BoTRAP2) from Babesia orientalis Parasites & Vectors 201912:200

4. Shu Ye, Ningbo Xia, Pengfei Zhao, Jichao Yang, Yanqin Zhou, Bang Shen*, Junlong Zhao*. Micronemal protein 13 contributes to the optimal growth of Toxoplasma gondii under stress conditions. Parasitol Res (2019) 118:935–944

5. Senyang Li, Jing Yang, Luyao Wang, Fen Du, Junlong Zhao*, Rui Fang*. Expression profile of microRNAs in porcine alveolar macrophages after Toxoplasma gondii infection. Parasites & Vectors (2019) 12:65

6. Yali Sun, Lan He*, Long Yu, Jiaying Guo, Zheng Nie, Qin Liu, Junlong Zhao*. Cathepsin L—a novel cysteine protease from Haemaphysalis flava Neumann, 1897. （2019）Parasitology Research. vol118(5)：1581-1592

7. 王宁 薛俊欣 丁佳乐 李健 赵俊龙 弓形虫蛋白质二硫键异构酶的免疫保护作用《中国兽医学报》2019年第6期1157-1162

8. Long Yu, Qin Liu, Xueyan Zhan, Yuan Huang, Yali Sun, Zheng Nie, Yangnan Zhao, Xiaomeng An,Muxiao Li, Sen Wang, Yangsiqi Ao, Cuiqin Huang, Lan He, Junlong Zhao*. Identification and molecular characterization of a novel Babesia orientalis thrombospondin-relatedanonymous protein (BoTRAP1). Parasites & Vectors (2018) 11:667

9. He L, He P, Luo X, Li M, Yu L, Guo J, Zhan X, Zhu G, Zhao J*.The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development. Parasit Vectors. 2018 Aug 6;11(1):452.

10. Yang J, Du F, Zhou X, Wang L, Li S, Fang R*, Zhao J*.Brain proteomic differences between wild-type and CD44- mice induced by chronic Toxoplasma gondii infection. Parasitol Res. 2018 Aug;117(8):2623-2633. 2.558

11. Song Q, Song W, Zhang W, He L, Fang R, Zhou Y, Shen B, Hu M, Zhao J*. Identification of erythrocyte membrane proteins interacting with Mycoplasma suis GAPDH and OSGEP.Res Vet Sci. 2018 Aug;119:85-90 1.616

12. Guo J, Li M, Sun Y, Yu L, He P, Nie Z, Zhan X, Zhao Y, Luo X, Wang S, Aoyang S, Liu Q, Huang C, He L, Zhao J. Characterization of a novel secretory spherical body protein in Babesia orientalis and Babesia orientalis-infected erythrocytes. Parasit Vectors. 2018 Jul 25;11(1):433.

13. Ming Pan, Yanqin Zhou, Yifan Wang, Longjiao Li, Yongle Song, Lun Hou, Junlong Zhao*. Screening and Identification of the Host Proteins Interacting with Toxoplasma gondii Rhoptry Protein ROP16. Frontiers in microbiology, 2017.12.4, 8

14. Li Tan, Yalin Li, Xin Yang, Qiyun Ke, Weiqiang Lei, Mudassar Niaz Mughal, Rui Fang, Yanqin Zhou, Bang Shen and Junlong Zhao*. Genetic diversity and drug sensitivity studies on Eimeria tenella field isolates from Hubei Province of China PARASITES & VECTORS MAR 9 2017

15. Lan He, Qin Liu, Baoan Yao, Yanqin Zhou, Min Hu, Rui Fang and Junlong Zhao* A Historical Overview of Research on Babesia orientalis, a Protozoan Parasite Infecting Water Buffalo FRONTIERS IN MICROBIOLOGY : 8 : 1323  JUL 14 2017

16. He L., Miao XY., Hu JF., Huang Y., He P., He JW., Yu L., Malobi N., Shi LG., Zhao JL* . First Molecular Detection of Babesia gibsoni in Dogs from Wuhan, China FRONTIERS IN MICROBIOLOGY : 8 : 1577 AUG 21 2017

17.王一凡，张伟超，吴 颢，李龙娇，周艳琴，方　瑞，申　邦，赵俊龙*.ＣＲＩＳＰＲ／Ｃａｓ９技术在构建弓形虫微线体蛋白ＭＩＣ３敲除株上的应用.中国兽医学报.２０１７年９月 第３７卷　第９期:1720-1725

18. Zhang W, Li L, Xia N, Zhou Y, Fang R, He L, Hu M, Shen B*, Zhao J*. Analysis of the virulence determination mechanisms in a local Toxoplasma strain (T.gHB1) isolated from central China. Parasitol Res. 2016 Oct;115(10):3807-15

19. Yifan Wang, Rui Fang, Yuan Yuan, Ming Pan, Min Hu, Yanqin Zhou, Bang Shen, Junlong Zhao*. Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3. Parasitology Research 115(7) July 2016: 2825–2835Lan He, Lizhe Fan ,Jinfang Hu , Xiaoyan Miao,Yuan Huang ,Yanqin Zhou , Min Hu, , Junlong Zhao*. Characterisation of a Babesia orientalis apical membrane antigen, and comparison of its orthologues among selected apicomplexans. Ticks and Tick-borne Diseases 6( 3), April 2015: 290–296

20. Yuan Huang, Lan He*, Jinfang Hu, Pei He, Junwei He, Long Yu, Ngabu Malobi, Yanqin Zhou,Bang Shen and JunLong Zhao*. Characterization and annotation of Babesia orientalis apicoplast genome. Parasites & Vectors (2015) 8:543

21. Lan He, Lizhe Fan, Qin Liu, Jinfang Hu, Xiaoyan Miao, Yuan Huang, Pei He, Junwei He, Long Yu, Muhammad Kasib Khan, Yanqin Zhou, Bang Shen, Junlong Zhao*. Identification and characterization of a novel 34 kDa merozoite protein in Babesia orientalis.Veterinary Parasitology(2015) 212( 3–4): 411-416

22. Wang Y, Fang R*, Yuan Y, Hu M, Zhou Y, Zhao J*. Identification of host proteins interacting with the integrin-like A domain of Toxoplasma gondii micronemal protein MIC2 by yeast-two-hybrid screening. Parasit Vectors. 2014, 7(1):543.

23. Qing Tao, Jiang Xiao, Yifan Wang, Kun Fang, Nizhi Li, Min Hu, Yanqin Zhou, and Junlong Zhao* (2014) Identification of Genes Expressed During Toxoplasma gondii Infection by in Vivo-Induced Antigen Technology (IVIAT) with Positive Porcine Sera. Journal of Parasitology: 100(4): 470-479.

24. Muhammad Khan, Lan He, Weichao Zhang, Yifan Wang, Qing Tao, Qiqi Song, Muhammad Sajid, Qian Yu, Jinfang Hu, Rui Fang, Min Hu, Yanqin Zhou, Junlong Zhao* Identification of two novel HSP90 proteins in Babesia orientalis: molecular characterization, and computational analyses of their structure, function, antigenicity and inhibitor interaction.Parasites & Vectors 2014, 7:293 (26 June 2014)

25. Lan He, Ying Zhang, Qing-Li Zhang, Wen-Jie Zhang, Hui-Hui Feng, Muhammad Khan, Min Hu, Yan-Qin Zhou, Jun-Long Zhao*. Mitochondrial genome of Babesia orientalis, apicomplexan parasite of water buffalo (Bubalus babalis, Linnaeus, 1758) endemic in China. Parasites & Vectors 2014, 7:82 (28 February 2014)

26. Lan He, Qian Yu, Wen-Jie Zhang, Qing-Li Zhang, Li-Zhe Fan, Xiao-Yan Miao, Muhammad Kasib Khan, Min Hu, Yan-Qin Zhou, Jun-Long Zhao*. Molecular cloning and characterization of a novel heat shock protein 20 of Babesia orientalis Veterinary Parasitology, 204( 3–4) 29 August 2014 : 177-183

27. Qian Yu, Lan He*, Wen-Jie Zhang, Jian-Xi Cheng, Jin-Fang Hu, Xiao-Yan Miao, Yuan Huang, Li-Zhe Fan, Muhammad Kasib Khan, Yan-Qin Zhou, Min Hu, Jun-Long Zhao*. Molecular cloning and characterization of Babesia orientalis rhoptry-associated protein 1 Veterinary Parasitology, 2014（205）499-505

28. Qiqi Song, Weijing Zhang, Weijiao Song, Zehua Liu,Muhammad Kasib Khan, Lan He, Rui Fang, Peng Li,Yanqin Zhou, Min Hu, Junlong Zhao∗ Seroprevalence and risk factors of Mycoplasma suis infectionin pig farms in central China. Preventive Veterinary Medicine 2014:117:215-221