职称 教授

学位  博士

政治面貌 九三学社社员

电话 027-87288505

邮箱 hyhan@mail.hzau.edu.cn

研究方向 纳米化学生物学

教育经历

1979.09-1983.07，安徽大学，理学学士

1988.09-1991.07，武汉大学，理学硕士

1997.09-2000.07，武汉大学，理学博士

主要职历

1991.07-1997.09，安徽淮南师范学院（师专），讲师/副教授

2000.09-2002.04，中国科学技术大学，博士后

2002.04-2004.08，美国Jackson State 大学，博士后

2004.09-现在，华中农业大学理学院，教授（二级岗）

科研成果

科研方向

主要科研方向包括：（1）纳米生物分析：基于仿生纳米器件（仿壁虎脚、治疗翅膀、花椰菜等）的荧光、电化学、电化学发光、表面增强拉曼光谱生物传感器的创制等，实现了对动物重大疫病病毒（猪伪狂犬病、猪圆环病、狂犬病等）及食品安全（黄曲霉毒素等）方便、灵敏和快速检测；（2）纳米材料抗超级细菌、抗植物病菌、抗动物病毒、抗肿瘤应用研究：基于纳米化学生物学的方法、技术和原理，构建了智能化纳米抗菌、抗肿瘤平台，用于超级细菌、植物病菌、动物病毒、肺癌、抗癌等光动力和光热治疗研究；纳米生物探针设计及其用于动物重大疫病致病机理研究等。

学术成绩

以第一作者或通讯作者在Chemical Society Reviews，Nature Communications，Science Advances, Advanced Materials, Advanced Functional Materials, ACS Nano, Analytical Chemistry等国际重要专业学术期刊发表SCI论文130多篇；获授权发明专利11项。。

代表性学术论文

1. Wu, Yang; Song, Zhiyong; Wang, Huajuan; Han, Heyou*. Endogenous stimulus-powered antibiotic release from nanoreactors for a combination therapy of bacterial infections. Nature communications, 2019, 10(1): 1-10.

2. Zhang, Jin; Xu, Mengqing; Mu, Yongli; Li, Jinjie; Foda, Mohamed F; Zhang, Weiyun; Han, Kai; Han, Heyou*, Reasonably retard O2 consumption through a photoactivity conversion nanocomposite for oxygenated photodynamic therapy. Biomaterials, 2019, 218, 119312.

3. Wang, Wenjing; Yu, Sha; Huang, Shan; Bi, Sai; Han, Heyou*; Zhang, Jian-Rong; Lu, Yi; Zhu, Jun-Jie*, Bioapplications of DNA nanotechnology at the solid-liquid interface. Chemical Society Reviews, 2019 , 48, 4892-4920

4. Liu, Jiawei; Wang, Shaoyan; Cai, Kai; Li, Yefei; Liu, Zhipan; Liu, Lingmei; Han, Yu; Wang, Hong; Han, Heyou*; Chen, Hongyu*, A New Type of Capping Agent in Nanoscience: Metal Cations. Small, 2019, 15, 1900444.

5. Zhang, Jin; Mu, Yong-Li; Ma, Zhao-Yu; Han, Kai; Han, He-You*, Tumor-triggered transformation of chimeric peptide for dual-stage-amplified magnetic resonance imaging and precise photodynamic therapy. Biomaterials , 2018, 182, 269-278.

6. Song, Zhiyong; Wu, Yang; Cao, Qi; Wang, Huajuan; Wang, Xiangru; Han, He-You*, pH-Responsive, Light-Triggered on-Demand Antibiotic Release from Functional Metal-Organic Framework for Bacterial Infection Combination Therapy. Advanced Functional Materials, 2018, 28 (23), 1800011.

7. Ma, Zhaoyu; Han, Kai; Dai, Xinxin; Han, He-You*, Precisely Striking Tumors without Adjacent Normal Tissue Damage via Mitochondria-Templated Accumulation. ACS Nano, 2018, 12(6), 6252-6262.

8. Ma, Jing; Wu, Long; Li, Zhonghua; Lu, Zhicheng; Yin, Wenmin; Nie, Axiu; Ding, Fan; Wang, Biru; Han, He-You*, Versatile Electrochemiluminescence Assays for PEDV Antibody Based on Rolling Circle Amplification and Ru-DNA Nanotags. Analytical Chemistry, 2018, 90 (12), 7415-7421.

9. Dai, Xinxin; Han, Kai; Ma, Zhaoyu; Han, He-You*, A Chimeric Peptide Logic Gate for Orthogonal Stimuli-Triggered Precise Tumor Therapy. Advanced Functional Materials, 2018, 28 (47), 1804609.

10. Zuo, Yunpeng; Rao, Dewei; Li, Shuo; Li, Tingting; Zhu, Guilin; Chen, Shuangming; Song, Li; Chai, Yang; Han, He-You*, Atomic Vacancies Control of Pd-Based Catalysts for Enhanced Electrochemical Performance. Advanced Materials, 2017, 30, 1704171.

11. Wang, Pan; Wu, Long; Lu, Zhicheng; Li, Qin; Yin, Wenmin; Ding, Fan; Han, He-You*, Gecko-Inspired Nanotentacle Surface-Enhanced Raman Spectroscopy Substrate for Sampling and Reliable Detection of Pesticide Residues in Fruits and Vegetables. Analytical Chemistry, 2017, 89 (4), 2424-2431.

12. Han, Kai; Zhang, Jin; Zhang, Weiyun; Wang, Shibo; Wu, Luming; Zhang, Chi; Zhang, Xianzheng; Han, He-You*, Tumor-Triggered Geometrical Shape Switch of Chimeric Peptide for Enhanced in Vivo Tumor Internalization and Photodynamic Therapy. ACS Nano, 2017, 11 (3), 3178-3188.

13. Kai Han, Wei-Yun Zhang, Jin Zhang, Qi Lei, Shi-Bo Wang, Jia-Wei Liu, Xian-Zheng Zhang, and He-You Han*, Acidity-Triggered Tumor-Targeted Chimeric Peptide for Enhanced Intra-Nuclear Photodynamic Therapy, Advanced Functional Materials, 2016, 26, 4351–4361.

14. Jiawei Liu, Yue Zheng, Zilan Hong, Kai Cai, Feng Zhao*, Han, He-You*, Microbial synthesis of highly dispersed PdAu alloy for enhanced electrocatalysis, Science Advances, 2016, 2, 9, e1600858.

15. Kang Shao, Biru Wang, Shiyi Ye, Yunpeng Zuo, Long Wu, Han, He-You*, Signal-Amplified Near-Infrared Ratiometric Electrochemiluminescence Aptasensor Based on Multiple Quenching and Enhancement Effect of Graphene/GoldNanorods/G-Quadruplex, Analytical Chemistry, 2016, 88, 8179-8187.

16. Chenchen Zou, Mohamed Frahat Foda, Xuecai Tan, Kang Shao, Long Wu, Zhicheng Lu, Hagar Shendy Bahlol, and Heyou Han*, Carbon-Dot and Quantum-Dot-Coated Dual-Emission Core−Satellite Silica Nanoparticles for Ratiometric Intracellular Cu2+ Imaging, Analytical Chemistry, 2016, 88, 7395-7403.

备注

农业微生物学国家重点实验室固定研究人员，入选“教育部新世纪优秀人才”，武汉市学科带头人，湖北省自然科学基金创新团队带头人，美国化学会会员，中国化学会会员，全国林业生物质材料标准化技术委员会委员；湖北省化学与化工学会常务理事；《Current Cancer Reports》、《Materials Physics and Chemistry》、《American Journal of Biomedical Sciences》、《分析科学学报》、《光散射学报》等杂志编委。2005-2014年任理学院院长，20014-2019年研究生院常务副院长，享受湖北省政府专项津贴和国务院政府特殊津贴。