Ling Zhao

Address: No.1, Shizishan Street, Hongshan District

Wuhan City, Hubei Province, P. R. China

Email: lingzhao@mail.hzau.edu.cn

Tel: +86-27-87285018(office)

Education Background

University of Georgia, Athens, GA, USA

Ph. D. in Veterinary Pathology , Aug 2009, Advisor: Dr. Zhenfang Fu

Huazhong Agricultural university, Wuhan, China

Ar. M. Preventive Veterinary, 2003, Advisor: Prof. Dingren Bi

    Ar. B. Veterinary, 2000

Professional Experience

2012-now     Professor, Department of Preventive Veterinary, College of Veterinary , Huazhong Agricultural university

2009-2012    Postdoctoral Researcher, Department of Microbiology, College of Medicine , University of Pennsylvania

Concurrent Academic

Member – The Society of Phi Zeta, the Honor Society of Veterinary Medicine, USA 2007-current，

                      American Society for Microbiology, USA 2008-current

Reviewer – Journal of Neurovirology，Viruses，Veterinary Microbiology，Virus Genes，Scientific Repors

Areas of Research Interests/ Research

Projects Areas of Research Interests/ Research Projects

His current research aims at understanding how rabies virus interacts with the host, especially how rabies virus evades the host immune responses.

Specifically:

● Understanding how rabies virus evades the host immune responses;

● Understanding how rabies vaccines induce the humoral immunity;

● Developing novel rabies vaccines and adjuvants;

● Developing novel therapeutic for rabies.

Honors And Awards

● 2015 National Natural Science Foundation--Outstanding Youth Foundation 

● 2010 Young Investigator Award for the 2010 Merial-NIH National Veterinary Scholars Symposium at University of Georgia, Athens, Georgia, August 5-8, 2010

● 2008 Travel funding for the 2008 American Society for Virology 27th annual meeting at Cornell University, Ithaca, New York, July 12-16, 2008 

Selected Publications

1. Yuan Y, Wang Z, Tian B, Zhou M, Fu ZF, Zhao L* Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.Arch Virol. 2019 Dec;164(12):2963-2974. doi: 10.1007/s00705-019-04415-6.

2. Pei J, Huang F, Wu Q, Luo Z, Zhang Y, Ruan J, Li Y, Zhou M, Fu Z, Zhao L*.Codon optimization n of G protein enhances rabies virus-induced humoral immunity. J Gen Virol. 2019 Aug;100(8):1222-1233. doi: 10.1099/jgv.0.001299. Epub 2019 Jul 1.

3. Luo Z, Li Y, Zhou M, Lv L, Wu Q, Chen C, Zhang Y, Sui B, Tu C, Cui M, Chen H, Fu ZF, Zhao L*. 2019. Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers. Front Immunol. 2019 Mar 8;10:429. doi: 10.3389/fimmu.2019.00429.

4. Chen C, Zhou M, Yan XG, Chen YX, Cui M, Chen HC, Fu ZF, Zhao L*.2019. A recombinant canine distemper virus expressing interleukin-7 enhances humoral immunity. J Gen Virol. 2019 Apr;100(4):602-615. doi: 10.1099/jgv.0.001247.

5. Tian B, Zhou M, Yang Y, Yu L, Luo ZC, Tian DY, Wang K, Cui M, Chen HC, Fu ZF*, Zhao L*. 2018. Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway. Front Immunol. 2018 Jan 19;8:2011. doi: 10.3389/fimmu.2017.02011.

6. Xia L, Li M, Zhang Y, Ruan J, Pei J, Shi J, Fu ZF, Zhao L, Zhou M, Tian D.2018. Exhaustive Exercise Does Not Affect Humoral Immunity and Protection after Rabies Vaccination in a Mouse Model.Virol Sin. 2018 Jun; 33(3):241-248. doi:10.1007/s12250-018-0026-1.

7. Zhao Wang, Qian Liang, Yajing Zhang, Jie Yang, Mingming Li, Kunlun Wang, Min Cui, Huanchun Chen, Zhen F. Fu, Ling Zhao*, Ming Zhou*. 2017. An optimized HMGB1 expressed by recombinant rabies virus enhances immunogenicity through activation of dendritic cells in mice. Oncotarget doi:10.18632/oncotarget.18368.

8. Chen T, Zhang Y, Wang Z, Yang J, Li M, Wang K, Cui M, Fu ZF, Zhao L*, Zhou M*. 2017. Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice. Virol Sin 32:317-327.

9. Wang Z, Li M, Zhou M, Zhang Y, Yang J, Cao Y, Wang K, Cui M, Chen H, Fu ZF, Zhao L*. 2017. A Novel Rabies Vaccine Expressing CXCL13 Enhances Humoral Immunity by Recruiting both T Follicular Helper and Germinal Center B Cells. J Virol 91.

10. Li Y, Zhou M, Luo Z, Zhang Y, Cui M, Chen H, Fu ZF, Zhao L*. 2017. Overexpression of IL-7 extends the humoral immune response induced by rabies vaccination. J Virol doi:10.1128/JVI.02324-16.

11. Zhang Y, Zhou M, Wang Z, Yang J, Li M, Wang K, Cui M, Chen H, Fu ZF, Zhao L*. 2016. Recombinant rabies virus expressing IL-21 enhances immunogenicity through activation of T follicular helper cells and germinal centre B cells. J Gen Virol 97:3154-3160.

12. Tian D, Luo Z, Zhou M, Li M, Yu L, Wang C, Yuan J, Li F, Tian B, Sui B, Chen H, Fu ZF, Zhao L*. 2016. Critical Role of K1685 and K1829 in the Large Protein of Rabies Virus in Viral Pathogenicity and Immune Evasion. J Virol 90:232-244.

13. Sui B, Huang J, Jha BK, Yin P, Zhou M, Fu ZF, Silverman RH, Weiss SR, Peng G, Zhao L*. 2016. Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. J Gen Virol doi:10.1099/jgv.0.000395.

14. Navid MT, Li Y, Zhou M, Cui M, Fu ZF, Tang L, Zhao L*. 2016. Comparison of the immunogenicity of two inactivated recombinant rabies viruses overexpressing the glycoprotein. Arch Virol 161:2863-2870.

15. Zhou M WL, Zhou S, Wang Z, Ruan J, Tang L, Jia Z, Cui M, Zhao L*, Fu ZF*. 2015. Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs. Oncotarget

16. Luo Z, Tian D, Zhou M, Xiao W, Zhang Y, Li M, Sui B, Wang W, Guan H, Chen H, Fu ZF, Zhao L*. 2015. lambda-Carrageenan P32 Is a Potent Inhibitor of Rabies Virus Infection. PLoS One 10:e0140586.

17. Zhao L, Birdwell LD, Wu A, Elliott R, Rose KM, Phillips JM, Li Y, Grinspan J, Silverman RH, Weiss SR. 2013. Cell-Type-Specific Activation of the Oligoadenylate Synthetase-RNase L Pathway by a Murine Coronavirus. J Virol 87:8408-8418.

18. Zhao L, Jha BK, Wu A, Elliott R, Ziebuhr J, Gorbalenya AE, Silverman RH, Weiss SR. 2012. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell Host Microbe 11:607-616.

19. Zhao L, Rose KM, Elliott R, Van Rooijen N, Weiss SR. 2011. Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus. J Virol 85:10058-10068.

20. Zhao L, Toriumi H, Wang H, Kuang Y, Guo X, Morimoto K, Fu ZF. 2010. Expression of MIP-1alpha (CCL3) by a recombinant rabies virus enhances its immunogenicity by inducing innate immunity and recruiting dendritic cells and B cells. J Virol 84:9642-9648.

21. Zhao L, Toriumi H, Kuang Y, Chen H, Fu ZF. 2009. The roles of chemokines in rabies virus infection: overexpression may not always be beneficial. J Virol 83:11808-11818.