Anding Zhang

Address: State Key Laboratory of Agricultural Microbiology, Room A-F116, Huazhong Agricultural University, Wuhan, 430070, China

Email: andye8019@mail.hzau.edu.cn

Tel: +86-27-87285018(office)

Education Background

Ph. D. in Animal infectious disease, 2008, Huazhong Agricultural University, Wuhan, 430070, China

Dissertation: “Identification, Characterization And Biofunction Study Of Novel Protective Antigens Of Streptococcus Suis Serotype 2.” (Advisor: Huanchun Chen)

B.S. in Animal Science, 2002, Huazhong Agricultural University, Wuhan, 430070, China 

Experience

Professor, Huazhong Agricultural University, 2016~Now

Associate Professor, Huazhong Agricultural University, 2011-2015

Postdoc., US Food and Drug Administration, MD, US, 2013-2014

Lecturer, College of Veterinary Medicine, Huazhong Agricultural University, 2008-2010

Areas of Research Interests/ Research

His current research focuses on the pathogenesis of Streptococcus suis, and he is also major in the treatment and control of animal infectious diseases. Until now, he has published more than 30 research articles.

Honors And Awards

The Nominating author of “the Award for National 100 Excellent Doctoral Dissertation of China”

“the First Prize for Excellent Research Paper” awards of Wuhan Association for Science and Technology.

National Science and Technology Progress Award (2011, 2016)

Hubei Science and Technology Progress Award (2007, 2013, 2015)

Representative Publications

[1] Fu, L., Han, L., Xie, C.Y., Li, W.K., Lin, L., Pan, S., Zhou, Y., Li, Z., Jin, M.L., and Zhang, A* (2017). Identification of Extracellular Actin As a Ligand for Triggering Receptor Expressed on Myeloid Cells-1 Signaling. Frontiers in Immunology 8, 917.

[2] Yu, C., Sizhu, S., Luo, Q., Xu, X., Fu, L. & Zhang, A*Genome sequencing of a virulent avian Pasteurella multocida strain GX-Pm reveals the candidate genes involved in the pathogenesis. Research in Veterinary Science, 2016, 105: 23-27.

[3] Zhao, J., L. Lin, L. Fu, L. Han, and Zhang, A*. 2016. Neutrophils extracellular Taps play an important role in clearance of Streptococcus suis in vivo. Microbiol Immunol 60:228-233.

[4] Fu, L., J. Zhao, L. Lin, Q. Zhang, Z. Xu, L. Han, C. Xie, R. Zhou, M. Jin, and Zhang, A*. 2016. Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2. Microbes Infect 18:285-289.

[5] Zhao, J., Pan, S., Lin, L., Fu, L., Yang, C., Xu, Z., Wei, Y., Jin, M. & Zhang, A*. Streptococcus suis serotype 2 strains can induce the formation of neutrophil extracellular traps (NETs) and evade trapping. FEMS Microbiol Lett, 2015, 362: pii: fnv022.

[6] Yang, C., Zhao, J., Lin, L., Pan, S., Fu, L., Han, L., Jin, M., Zhou, R. & Zhang, A*. Targeting TREM-1 Signaling in the Presence of Antibiotics is Effective Against Streptococcal Toxic-Shock-Like Syndrome (STSLS) Caused by Streptococcus suis. Front Cell Infect Microbiol, 2015, 5: 79.

[7] Yang, C., Chen, B., Zhao, J., Lin, L., Han, L., Pan, S., Fu, L., Jin, M., Chen, H. & Zhang, A*. TREM-1 signaling promotes host defense during the early stage of infection with the highly pathogenic Streptococcus suis. Infect Immun, 2015, 83: 3293-301.

[8] Lin, L., Pan, S., Zhao, J., Liu, C., Wang, P., Fu, L., Xu, X., Jin, M. & Zhang, A*. HSPD1 interacts with IRF3 to facilitate interferon-beta induction. PLoS One, 2014, 9: e114874.

[9] Zhang A, Chen, B., et al., HP0197 Contributes to CPS Synthesis and the Virulence of Streptococcus suis via CcpA, PlosOne 2012, 7(11):e50987

[10] Zhang, A., Mu, X., Chen, B., Han, L., Chen, H., and Jin, M. IgA1 protease contributes to the virulence of Streptococcus suis. Vet Microbiol. 2011;148:436-439.

Representative projects

1. Development of new technology on detection of avian infectious diseases

2. Study on evasion of swine neutrophils extracellular traps-mediated killing by Streptococcus suis

3. Study on the role and mechanism of IL-17 induced by Streptococcus suis on Streptococcal toxic shock-like syndrome (STSLS)

4. Study of activation mechanism of inflammasome by infection with Streptococcus suis

5. Study on the molecular mechanism of regulation of virulence in Streptococcus suis by XRE Family regulator PrlP