Guiqing Peng is a professor in the Department of Veterinary Medicine, and a permanent staff in the State Key Laboratory of Agricultural Microbiology at Huazhong Agricultural University. His current research aims at elucidating the receptor recognition and replication mechanisms of Coronavirus, thus developing new vaccine and antiviral drugs.
Address: The Cooperative Innovation Center for Sustainable Pig Production, Room N-410, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070China
Tel: +86-27-87285816 (office);
Email: penggq@mail.hzau.edu.cn
Education Background
Ph.D. Microbiology, June 2007, Wuhan University, Wuhan, China
Thesis: “Study on the biological function of Borna Disease Virus Phosphoprotein.” (Advisor: Professor Jianguo Wu)
MS. Preventive Veterinary Medicine, 2004, Huazhong Agricultural University, Wuhan, P. R. China
Thesis: “Study on Expression of the Carboxy(C)-terminal VP1 Gene of FMDV and Porcine Interferon-alpha/beta Gene in Escherichia coli.” (Advisor: Professor and academician Huanchun Chen)
DVM. Veterinary Medicine, 2001,Huazhong Agricultural University, Wuhan, P. R. China
Experience
Professor, Department of Preventive Veterinary Medicine, College of veterinary medicine, Huazhong Agricultural University, 2012-now
Postdoctoral Researcher, Department of Pharmacology, University of Minnesota, USA, 2009-2012
Assistant professor, Wuhan Institute of Virology, Chinese Academy of Sciences, 2007-2008
Concurrent Academic
Director of Hubei Province Crystal Society
The reviewer of Virology and JGV
Areas of Research Interests/ Research
2020
Shang J, Wan Y, Liu C, Yount B, Gully K, Yang Y, Auerbach A, Peng G, Baric R, Li F. Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. PLoS Pathog. 2020 Mar 9;16(3):e1008392
Ye G, Wang X, Tong X, Shi Y, Fu ZF, Peng G*. Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376.Viruses. 2020 Feb 21;12(2). pii: E240. doi: 10.3390/v12020240.
2019
Dong W, Xie W, Liu Y, Sui B, Zhang H, Liu L, Tan Y, Tong X, Fu ZF, Yin P, Fang L, Peng G*. Receptor tyrosine kinase inhibitors block proliferation of TGEV mainly through p38 mitogen-activated protein kinase pathways. Antiviral Res. 2019 Nov 18;173:104651.
Yu L, Shen Z, Liu Q, Zhan X, Luo X, An X, Sun Y, Li M, Wang S, Nie Z, Ao Y, Zhao Y, Peng G, Mamoun CB, He L, Zhao J. Crystal structures of Babesia microti lactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis. FASEB J. 2019 Oct 4:fj201901259R.
Mi D, Ou X, Li P, Peng G, Liu Y, Guo R, Mu Z, Li F, Holmes K, Qian Z. Glycine 29 Is Critical for Conformational Changes of the Spike Glycoprotein of Mouse Hepatitis Virus A59 Triggered by either Receptor Binding or High pH. J Virol. 2019 Sep 30;93(20).
Shen Z, Wang G, Yang Y, Shi J, Fang L, Li F, Xiao S, Fu ZF, Peng G*. A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence. J Biol Chem. 2019 Sep 13;294(37):13606-13618.
Wang G, Liang R, Liu Z, Shen Z, Shi J, Shi Y, Deng F, Xiao S, Fu ZF, Peng G*.The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in Piglets.Viruses. 2019 Mar 30;11(4).
Xie W, Ao C, Yang Y, Liu Y, Liang R, Zeng Z, Ye G, Xiao S, Fu ZF, Dong W, Peng G*.Two critical N-terminal epitopes of the nucleocapsid protein contribute to the cross-reactivity between porcine epidemic diarrhea virus and porcine transmissible gastroenteritis virus.J Gen Virol. 2019 Feb;100(2):206-216.
2018
Luo G, Zhu X, Lv Y, Lv B, Fang J, Cao S, Chen H, Peng G, Song Y.Crystal Structure of the Dimerized N Terminus of Porcine Circovirus Type 2 Replicase Protein Reveals a Novel Antiviral Interface.J Virol. 2018 Aug 29;92(18).
Zeng Z, Deng F, Shi K, Ye G, Wang G, Fang L, Xiao S, Fu Z, Peng G*. Dimerization of Coronavirus nsp9 with Diverse Modes Enhances Its Nucleic Acid Binding Affinity.J Virol. 2018 Aug 16;92(17).
Shen Z, Ye G, Deng F, Wang G, Cui M, Fang L, Xiao S, Fu ZF, Peng G*. Structural Basis for the Inhibition of Host Gene Expression by Porcine Epidemic Diarrhea Virus nsp1.J Virol. 2018 Feb 12;92(5).
Zheng A, Shi Y, Shen Z, Wang G, Shi J, Xiong Q, Fang L, Xiao S, Fu ZF, Peng G*. Insight into the evolution of nidovirus endoribonuclease based on the finding that nsp15 from porcine Deltacoronavirus functions as a dimer.J Biol Chem. 2018 Aug 3;293(31):12054-12067.
Fang P, Fang L, Ren J, Hong Y, Liu X, Zhao Y, Wang D, Peng G, Xiao S.Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA. J Virol. 2018 Jul 17;92(15).
Zhu X, Liu S, Wang X, Luo Z, Shi Y, Wang D, Peng G, Chen H, Fang L, Xiao S.Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection.Emerg Microbes Infect. 2018 Apr 11;7(1):65.
Shi Y, Lei Y, Ye G, Sun L, Fang L, Xiao S, Fu ZF, Yin P, Song Y, Peng G*.Identification of two antiviral inhibitors targeting 3C-like serine/3C-like protease of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus.Vet Microbiol. 2018 Jan;213:114-122.
2017
Zeng Z, Li TT, Jin X, Peng FH, Song NH, Peng GQ*, Ge XY*. Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016. Virol Sin. 2017 Aug;32(4):298-306.
Zhu X, Wang D, Zhou J, Pan T, Chen J, Yang Y, Lv M, Ye X, Peng G, Fang L, Xiao S.Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2. J Virol. 2017 Apr 28;91(10). pii: e00003-17.
Peng G, Yang Y, Pasquarella JR, Xu L, Qian Z, Holmes KV, Li F.Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor. J Biol Chem. 2017 Feb 10;292(6):2174-2181.
2016
Fang J, Li H, Kong D, Cao S, Peng G, Zhou R, Chen H, Song Y.Structure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virus. Sci Rep. 2016 Sep 29;6:34550.
Ye G, Deng F, Shen Z, Luo R, Zhao L, Xiao S, Fu ZF, Peng G*. Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease. Virology. 2016 Jul;494:225-35.
Shi Y, Li Y, Lei Y, Ye G, Shen Z, Sun L, Luo R, Wang D, Fu ZF, Xiao S, Peng G*. A Dimerization-Dependent Mechanism Drives the Endoribonuclease Function of PRRSV nsp11. J Virol. 2016 Feb 24. pii: JVI.03065-15.
Wang J, Deng F, Ye G, Dong W, Zheng A, He Q, Peng G*. Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses. Virol Sin. 2016 Feb;31(1):49-56.
Deng F, Ye G, Liu Q, Navid MT, Zhong X, Li Y, Wan C, Xiao S, He Q*, Fu ZF*, Peng G*. Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains. Viruses. 2016 Feb 23;8(3). pii: E55.
Sui B, Huang J, Jha BK, Yin P, Zhou M, Fu ZF, Silverman RH, Weiss SR, Peng G*, Zhao L*. Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. J Gen Virol. 2016 Jan 12.
Li Y, Dong W, Shi Y, Deng F, Chen X, Wan C, Zhou M, Zhao L, Fu ZF*, Peng G*. Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication. Virology. 2016 Jan 15;488:216-24.
2015
Wang D，Fang L，Shi Y，Zhang H，Gao L，Peng G，Chen H，Li K，Xiao S.Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO，J Virol. 2015，90（4）：2090-2101.
Dong W, Huang J, Li Y, Tan Y, Shen Z, Song Y, Wang D, Xiao S, Chen H, Fu ZF*, Peng G*. Crystal structural basis for Rv0315, an immunostimulatory antigen and inactive beta-1,3-glucanase of Mycobacterium tuberculosis. Sci Rep. 2015 Oct 15;5:15073.
Liu C，Tang J，Ma Y，Liang X，Yang Y，Peng G，Qi Q，Jiang S，Li J，Du, L，Li F. Receptor usage and cell entry of porcine epidemic diarrhea coronavirus，J Virol. 2015，89（11）：6121-6125.
2014
Zhang Y, Li H, Peng G, Zhang Y, Gao X, Xiao S, Cao S, Chen H, Song Y.Mutational analysis of the functional sites in porcine reproductive and respiratory syndrome virus non-structural protein 10. J Gen Virol. 2015 Mar;96(Pt 3):547-52. doi: 10.1099/jgv.0.000004. Epub 2014 Dec 5.
Zhang H, Li X, Peng G, Tang C, Zhu S, Qian S, Xu J, Qian P.Glycoprotein E2 of classical swine fever virus expressed by baculovirus induces the protective immune responses in rabbits.Vaccine. 2014 Nov 20;32(49):6607-13.
2013
Fang J, Sun L, Peng G, Xu J, Zhou R, Cao S, Chen H, Song Y.Identification of three antiviral inhibitors against Japanese encephalitis virus from library of pharmacologically active compounds 1280.PLoS One. 2013 Nov 4;8(11):e78425.
Fang J, Li H, Peng G, Cao S, Zhen FF, Chen H, Song Y.Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese encephalitis virus NS3 helicase.J Virol Methods. 2013 Dec;194(1-2):33-8.
2012
Peng G, Xu L, Chen L, Lin YL, Chen L, Pasquarella JR, Holmes KV, Li F. Crystal structure of bovine coronavirus spike protein lectin domain. J Biol Chem. 2012. Dec 7;287(50):41931-8.
Chen L, Lin YL, Peng G, Li F. Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc Natl AcadSci U S A. 2012 Oct 30;109(44):17966-71.
Wu K#, Peng G# (Co-first author), Wilken M#, Geraghty RJ, Li F. Mechanism of Host Receptor Adaptation by SARS Coronavirus. J Biol Chem. 2012 ;287(12):8904-11.
2011
Peng G, Sun D, Rajashankar K, Qian Z, Holmes K, Li F. Structure of mouse coronavirus galectin-likedomain complexed with its protein receptor. Proc Natl AcadSci U S A. 2011 Jun 16, 108, 10696-10701.
Wu K, Chen L, Peng G, Zhou W, Pennell CA, Mansky LM, Geraghty RJ, Li F.A Virus-binding Hotspot on Human Angiotensin-converting Enzyme 2 is Critical for the Binding of Two Different Coronaviruses. J Virol. 2011 Mar; 85, 5331-5337.
2004-2010
Wu K, Li W, Peng G, Li F. Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor. Proc Natl AcadSci U S A. 2009 Nov 24;106(47):19970-4.
Zhu C, Zhang R, Liu D, Mukhtar MM, Liu W, Peng G, Wang K, Hao Q, Xu Y, Liu F, Zhu Y, Wu J.Association of functional polymorphism of ApoB promoter with hepatitis C virus infection. ClinChimActa. 2009 Mar;401(1-2):124-7.
Peng G, Yan Y, Zhu C, Wang S, Yan X, Lu L, Li W, Hu J, Wei W, Mu Y, Chen Y, Feng Y, Gong R, Wu K, Zhang F, Zhang X, Zhu Y, Wu J. Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein. J Virol. 2008 Dec;82(24):12487-97.
Feng Y, Wang S, Luo F, Ruan Y, Kang L, Xiang X, Chao T, Peng G, Zhu C, Mu Y, Zhu Y, Zhang X, Wu J.A novel recombinant bacterial vaccine strain expressing dual viral antigens induces multiple immune responses to the Gag and gp120 proteins of HIV-1 in immunized mice.Antiviral Res. 2008 Dec;80(3):272-9.
Li W, Liu Y, Mukhtar MM, Gong R, Pan Y, Rasool ST, Gao Y, Kang L, Hao Q, Peng G, Chen Y, Chen X, Wu J, Zhu Y.Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection. PLoS One. 2008 Apr 16;3(4):e1985.
Lu L, Wei L, Peng G, Mu Y, Wu K, Kang L, Yan X, Zhu Y, Wu J.NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways.Virology. 2008 Feb 5;371(1):61-70. Epub 2007 Oct 26.
Peng G, Zhang F, Zhang Q, Wu K, Zhu F, Wu J. Borna disease virus P protein inhibits nitric oxide synthase gene expression in astrocytes. Virology. 2007 Sep 30;366(2):446-52.
Qian P, Li XM, Jin ML, Peng GQ, Chen HC. An approach to a FMD vaccine based on genetic engineered attenuated pseudorabies virus: one experiment using VP1 gene alone generates an antibody responds on FMD and pseudorabies in swine. Vaccine. 2004 Jun 2;22(17-18):2129-36.
Honors And Awards
● The National Science Fund for Excellent Young Scholars, China, 2017.
● Chang Jiang Scholars Program, China, 2016.
● National Youth Top Talent Support Program of National High-level Personnel of Special Support Program, China, 2015.
● The first prize of the 13th Hubei Provincial Natural Science excellent academic thesis, china, 2012.
● Christophe Meriux Award, The seventh session of the International Society of Virology, china, 2007.
