Dr. Bo Li

Professor

State Key Laboratory of Agricultural Microbiology

College of Plant Science and Technology

Huazhong Agricultural University

Wuhan, Hubei 430070 P.R. China

Tel：(+86)027-87288266

Email：boli@mail.hzau.edu.cn

EDUCATION

2006.09-2011.06 Ph.D in Plant Pathology, Huazhong Agricultural University 2002.09-2006.06 B. A. in Plant Protection, Huazhong Agricultural University

PROFESSIONAL EXPERIENCE

2017.01-present Professor, Department of Plant Pathology，Huazhong Agricultural University

2015.05-2016.11 Assistant Research Scientist, Department of Plant Pathology and Microbiology, Texas A&M University

2013.01-2015.04 Postdoctoral Research Associate, Department of Plant Pathology and Microbiology, Texas A&M University

2011.12-2012.12 Visiting Scholar, Department of Biochemistry and Biophysics, Texas A&M University

2011.07-2011.11 Lecturer, College of Plant Science and Technology, Huazhong Agricultural University

RESEARCH INTERESTS

My laboratory focuses on signaling networks regulating plant innate immunity and mechanisms of the plant-microbe interaction through molecular biology, biochemical and genetic approaches. My long-term goal is to improve crop resistance towards plant pathogens by genetic improvement. Currently we are interested in: (1) mechanisms of plant immune genes expression governed by various types of transcription factors and epigenetic modification; (2) cloning and identification of tomato PRRs recognizing PAMPs from Ralstonia solanacearum and elucidation of the molecular function and signaling transduction; (3) mechanism of protein post-translational modification in plant immune signaling.

FUNDINGS

1. Dissection of the mechanism for Ralstonia solanacearum hijack TGA transcription factors to subvert plant immune gene expression, Natural Science Foundation of China, 2020-2023.

2. Transcriptional regulation of plant innate immunity by Trihelix transcription factors, Natural Science Foundation of China, 2018-2021.

3. The mechanism of tomato resistance to Ralstonia solanacearum. Huazhong Agricultural University Scientific & Technological Self-innovation Foundation, 2017-2021

SELECTED PUBLICATIONS

1. Bo Li^#*, Marco Aurélio Ferreira^#, Mengling Huang, Luiz Fernando Camargos, Xiao Yu, Ruan M. Teixeira, Paola A. Carpinetti, Giselle C. Mendes, Bianca C. Gouveia-Mageste, Chenglong Liu, Claudia S.L. Pontes, Otávio J.B. Brustolini, Laura G.C. Martins, Bruno P. Melo, Christiane E.M. Duarte, Libo Shan, Ping He and Elizabeth P. B. Fontes* (2019) The receptor-like kinase NIK1 targets FLS2/BAK1immune complex and inversely modulates antiviral and antibacterial immunity. Nature Communications 10:4996 

2. Bo Li^#, Xiangzong Meng^#, Libo Shan and Ping He^* (2016) Transcriptional regulation of pattern-triggered immunity in plants. Cell Host & Microbe 19(5):641-650. 

3. Marcos Oliveira^#, Guangyuan Xu^#, Bo Li^#, Luciano Vespoli, Xiangzong Meng, Xin Chen, Xiao Yu, Suzane Ariádina de Souza, Aline C. Intorne, Abbey L. Babinat, Hisashi Koiwa, Gonçalo A. de Souza Filho, Libo Shan and Ping He^* (2016) Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation. Nature Plant 15218

4. Bo Li^#, Shan Jiang^#, Xiao Yu, Cheng, Cheng, Shixue Chen, Yanbing Cheng, Joshua Yuan, Daohong Jiang, Ping He and Libo Shan^* (2015) Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity. The Plant Cell 27: 839–856.

5. Wenwei Lin^#, Bo Li^#, Dongping Lu, Sixue Chen, Ning Zhu, Ping He and Libo Shan^* (2014) Tyrosine phosphorylation of protein kinase complex BAK1/BIK1 mediates Arabidopsis innate immunity. Proc Natl Acad Sci USA 111 (9) 3632-3637. 

6. Bo Li^#, Dongping Lu^# and Libo Shan^* (2014) Ubiquitination of pattern recognition receptors in plant innate immunity. Mol Plant Pathol 15(7): 737–746. 

7. Xiao Yu^#, Bo Li^#, Yanping Fu, Jiatao Xie, Jiasen Cheng, Said A. Ghabrial, Guoqing Li, Xianhong Yi and Daohong Jiang^* (2013) Extracellular transmission of a DNA mycovirus and its use as a natural fungicide. Proc Natl Acad Sci USA 110(4): 1452-1457

8. Xiao Yu^#, Bo Li^#, Yanping Fu, Daohong Jiang^*, Said A. Ghabrial, Guoqing Li, Youliang Peng, Jiatao Xie, Jiasen Cheng, Junbin Huang and Xianhong Yi（2010）A geminivirus-related DNA mycovirus that confers hypovirulence to a plant pathogenic fungus. Proc Natl Acad Sci USA 107:8387-8392. 

9. Bo Li, Yanping Fu, Daohong Jiang^*, Jiatao Xie, Jiasen Cheng, Guoqing Li, Mahammad Imran Hamid and Xianhong Yi (2010) Cyclic GMP as a second messenger in the nitric oxide mediated conidiation of the mycoparasite Coniothyrium minitans. Appl Environ Microb 76: 2830–2836.

OTHER PUBLICATIONS 

10. Xiao Yu^#, Guangyuan Xu^#, Bo Li, Luciano de Souza Vespoli, Hai Liu, Wolfgang Moeder, Sixue Chen, Marcos V.V. de Oliveira, Suzane Aria´dina de Souza, Wenyong Shao, Ba´rbara Rodrigues, Yi Ma, Shweta Chhajed, Shaowu Xue, Gerald A. Berkowitz, Keiko Yoshioka, Ping He* and Libo Shan* (2019) The receptor kinases BAK1/SERK4 regulate Ca²⁺ channel-mediated cellular homeostasis for cell death containment. Current Biology 29, 1–13

11. Xiao Yu, Bo Li, Geng-Jen Jang, Shan Jiang,1 Daohong Jiang,3 Jyan-Chyun Jang, Shu-Hsing Wu, Libo Shan, and Ping He (2019) Orchestration of processing body dynamics and mRNA decay in Arabidopsis immunity. Cell Reports 28, 2194–2205

12. Feng Ding, Jiasen Cheng, Yanping Fu, Tao Chen, Bo Li, Daohong Jiang and Jiatao Xie (2019) Early transcriptional response to DNA virus infection in Sclerotinia sclerotiorum. Viruses 11:278

13. Cheng Xiong, Dan Luo, Aihua Lin, Chunli Zhang, Libo Shan, Ping He, Bo Li, Qiaomei Zhang,Bin Hua, Zilv Yuan, Hanxia Li, Junhong Zhang, Changxian Yang, Yongen Lu, Zhibiao Ye and Taotao Wang. (2019) A tomato B-box protein SlBBX20 modulates carotenoid biosynthesis by directly activating PHYTOENE SYNTHASE 1, and is targeted for 26S proteasome-mediated degradation New Phytologist 221: 279–294

14. Feng Yi Cao, Thomas A. DeFalco, Wolfgang Moeder, Bo Li, Yunchen Gong, Xiao-Min Liu, Masatoshi Taniguchi, Shelley Lumba, Shigeo Toh, Libo Shan, Brian Ellis, Darrell Desveaux and Keiko Yoshioka (2018) Arabidopsis ETHYLENE RESPONSE FACTOR 8 (ERF8) has dual functions in ABA signaling and immunity. BMC Plant Biology 18:211

15. Hongchang Ran, Lijiang Liu, Bo Li, Jiasen Cheng, Yanping Fu, Daohong Jiang, and Jiatao Xie. (2016) Co-infection of a hypovirulent isolate of Sclerotinia sclerotiorum with a new botybirnavirus and a strain of a mitovirus. Virology Journal 13:92

16. Si Liu, Jiatao Xie, Jiasen Cheng, Bo Li, Tao Chen, Yanping Fu, Guoqing Li, Manqun Wang, Huanan Jin, Hu Wan, and Daohong Jiang^*.（2016） Fungal DNA virus infects a mycophagous insect and utilizes it as a transmission vector. Proc Natl Acad Sci USA. 2016.113(45)：12803-12808

17. Xiangzong Meng, Jinggeng Zhou, Jiao Tang, Bo Li, Marcos V. V. de Oliveira, Jijie Chai, Ping He and Libo Shan^* (2016) Ligand-induced receptor-like kinase complex regulates floral organ abscission in Arabidopsis. Cell Reports 14(6): 1330-1338.(IF=8.358)

18. Baomin Feng, Chenglong Liu, Marcos Oliveira, Aline C. Intorne, Bo Li, Kevin Babilonia, Gonçalo A. de Souza Filho, Libo Shan and Ping He^* (2015) Protein poly(ADP-ribosyl)ation regulates Arabidopsis immune gene expression and defense responses. PLOS Genetics 11(1): e1004936. doi:10.1371/journal. pgen. 1004936.(IF=7.528)

19. Fangjun Li^#, Cheng Cheng^#, Fuhao Cui^#, Marcos V.V. de Oliveira^#, Xiao Yu, Xiangzong Meng, Aline C. Intorne, Kevin Babilonia, Maoying Li, Bo Li, Sixue Chen, Xianfeng Ma, Shunyuan Xiao, Yi Zheng, Zhangjun Fei, Richard P. Metz, Charles D. Johnson, Hisashi Koiwa, Wenxian Sun, Zhaohu Li, Gonçalo A. de Souza Filho, Libo Shan^* and Ping He^* (2014) Modulation of RNA Polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity. Cell Host Microbe 16(6): 2014 748–758. (IF=12.328)

20. Wei Wei, Wenjun Zhu, Jiasen Cheng, Jiatao Xie, Bo Li, Daohong Jiang, Guoqing Li, Xianhong Yi and Yanping Fu^* (2013) CmPEX6, a Gene involved in peroxisome biogenesis, is essential for parasitism and conidiation by the sclerotial parasite Coniothyrium. minitans. Appl Environ Microb 79 (12): 3658 –36667. (IF=3.668)

21. Jiahong Zhou, Yanping Fu, Jiatao Xie, Bo Li, Daohong Jiang, Guoqing Li and Jiasen Cheng^* (2012) Identification of microRNA-like RNAs in a plant pathogenic fungus Sclerotinia sclerotiorum by high-throughput sequencing. Mol Genet Genomics 287:275–282. (IF=2.728) 

22. Huiquan Liu, Yanping Fu, Bo Li, Xiao Yu, Jiatao Xie, Jiasen Cheng, Said A Ghabrial, Guoqing Li, Xianhong Yi and Daohong Jiang^* (2011) Widespread Horizontal Gene Transfer from Circular Single-stranded DNA Viruses to Eukaryotic Genomes. BMC Evol Biol 11:276 (IF=3.368)

23. Jiatao Xie, Yanping Fu, Daohong Jiang^*, Guoqing Li, Junbin Huang, Bo Li, Tom Hsiang and Youliang Peng (2008) Intergeneric transfer of ribosomal genes between two fungi. BMC Evol Biol 8:87 (IF=3.368)