Weicheng Bei

Positional Title：Professor

Degree：Ph.D.

Email：beiwc@mail.hzau.edu.cn

Research Directions：Animal Infectious Disease Prevention and Control

Education

Ph.D. Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, 9/2000 – 6/2005

B.S. Animal Science, Huazhong Agricultural University, Wuhan, China, 9/1995 – 6/1999

Experience

Professor, College of Veterinary Medicine, Huazhong Agricultural University, 2012 – now

Associate Professor, College of Veterinary Medicine, Huazhong Agricultural University, 2007 – 2017

lecturer, College of Veterinary Medicine, Huazhong Agricultural University, 2005 – 2017

Postdoctoral Associate, Biochemistry, Florida International University, Florida, Miami, 8/2011 –8/2012

Scientific Research Results

Research Interest

He mainly focuses on the pathogens of porcine bacterial respiratory disease syndrome such as APP, HPS and SS2, from the etiology and epidemiology, genomic and functional genomics, pathogenicity and immune mechanism, new vaccines and molecular diagnostic reagents research and creation scientific research on comprehensive prevention and control shutdown technology of major animal diseases. His main research directions include: (1) The genome and functional genomics of important animal pathogenic bacteria; (2) The molecular pathogenicity and immune mechanism of important animal pathogenic bacteria; (3) The molecular design and creation of new vaccines, diagnostic reagents and new drugs for important animal diseases.

Academic Contribution

He has presided over and undertaken 4 projects of National Natural ScienceFoundation of China, 1 project of Ministry of Education New Century Talent Support Program, 1 project of Special Fund for Agro-scientific Research in the Public Interest of Ministry of Agriculture, 1 project of Excellent Youth Foundation of Hu’bei Scientific Committee, 1 project of Research and Development of Hubei Province.He participated in 2 projects of National Program on Key Basic Research Project (973 Program),2 projects of National High-tech R&D Program of China (863 Program).Published 48 SCI-accepted papers in the journals of Virulence, JID, JB, Vaccine, Veterinary Microbiology, etc. as the first or corresponding author.In 2013 and 2014, he won the first prize of Scientific and Technological Progress of Hubei Province, and in 2018 he won the First Prize of achievement promotion in Hubei Province. Obtained 2 projects of National new Veterinary Drug Registration Certificate, 4 projects of Agricultural Genetically Modified Biosafety, 2 cases of Evaluation Certificates, and the First Completion Authorized National Invention Patent, 3 projects of Transformation of Scientific and Technological Achievements.

Funded Project

1. National Natural Science Foundation of China, “Study on the mechanism of the two-component regulatory system 1094hk/rr involved in the highly pathogenic Streptococcus suis type 2 induced inflammatory response” (PI, Grant No.31372466), 2014-2017.

2. Special Fund for Agro-scientific Research in the Public Interest of Ministry of Agriculture, “Porcine contagious Pleuropneumonia vaccine development and industrialization” (PI, Grant No.201303034), 2013-2017.

3. National Natural Science Foundation of China, “Research on the Pathogenic Mechanism of Actinobacillus pleuropneumoniae Controlled by Two-component Signal Transduction System CpxA/CpxR” (PI, Grant No. 30970109), 2010-2012.

4. National Natural Science Foundation of China Youth Fund , “Construction of a mutant strain of Actinobacillus pleuropneumoniae toxin apxIV gene deletion and its biological characteristics” (PI, Grant No.30600025) , 2007-2009.

5. Ministry of Education New Century Talent Support Program, “Molecular Mechanism of RaeS / RaeR Induced Acute Inflammation in Hosts by a Novel Two-component Regulatory System of Streptococcus suis Type 2”(PI, Grant No.NCET-12-0858), 12/2012-12/2015.

6. Excellent Youth Foundation of Hu’bei Scientific Committee, “Two-component regulatory system ciaRH hk / rr participates in the mechanism of inflammatory response induced by highly pathogenic Streptococcus suis type 2”(Grant No.2013CFA033, 1/2014-12/2016.

7. National High-tech R&D Program of China (863 Program), “Veterinary Drug Functional Genome”(PI, Grant No.2010AA10A202), 2010-2011.

8. National Program on Key Basic Research Project (973 Program), “Immune response and immune escape mechanism of pathogenic bacteria”(CO-PI, Grant No.2012CB518805), 2011-2016.

9. National Program on Key Basic Research Project (973 Program), “Study on Molecular Immunity Mechanism of Important Animal Pathogens”(CO-PI, Grant No.2006CB504404), 2006-2010.

10. National Science & Technology Pillar Program during the Eleventh Five-Year Plan Period, “Study on the Interaction between Pathogen, Host and Cell”(PI, Grant No.2006BAD06A04), 2006-2008.

11. Research and Development of Hubei Province, “"Development and demonstration of genetically engineered vaccines for Porcine contagious pleuropneumonia, Haemophilus parasuis and Streptococcus"(PI, Grant No.2011BBB082), 2011-2014.

12. National High-tech R&D Program of China (863 Program), “Research and creation of genetically engineered vaccines for important bacterial diseases in livestock and poultry”(CO-PI, Grant No.2006AA10A206), 2006-2010.

Major Publications

1. Hu J, Xu J, Liu F, Tan C, Yuan F, Chen H, Bei W*. Immunogenicity and cross-protective efficacy of double-mutant Streptococcus suis ΔSspepO/ΔSspspC serotypes 2 and 7. Vaccine. 2019 Apr 10;37(16):2194-2199.

2. Xu J, Zhang N, Cao M, Ren S, Zeng T, Qin M, Zhao X, Yuan F, Chen H, Bei W*. Identification of Three Type II Toxin-Antitoxin Systems in Streptococcus suis Serotype 2. Toxins (Basel). 2018 Nov 13;10(11).

3. Liu F, Peng W, Liu T, Zhao H, Yan K, Yuan F, Chen H, Bei W*. Biological role of Actinobacillus pleuropneumoniae type IV pilus proteins encoded by the apf and pil operons. Vet Microbiol. 2018 Oct;224:17-22.

4. Chang P, Li W, Shi G, Li H, Yang X, Xia Z, Ren Y, Li Z, Chen H, Bei W*. The VraSR regulatory system contributes to virulence in Streptococcus suis via resistance to innate immune defenses. Virulence. 2018 Dec 31;9(1):771-782.

5. Liu F, Li J, Yan K, Li H, Sun C, Zhang S, Yuan F, Wang X, Tan C, Chen H, Bei W*. The role of the Streptococcus suis protein SsPepO in the development of meningitis. The Journal of Infectious Diseases. 2018 Mar 5;217(6):973-982.

6. Li H, Liu F, Peng W, Yan K, Zhao H, Liu T, Cheng H, Chang P, Yuan F, Chen H, Bei W* CpxA/CpxR two-component system affects biofilm formation and virulence in Actinobacillus pleuropneumoniae. Front Cell Infect Microbiol. 2018 Mar 20;8:72.

7. Zheng C, Zhao X, Zeng T, Cao M, Xu J, Shi G, Li J, Chen H, Bei, W*. Identification of four typeII toxinantitoxin systems in Actinobacillus pleuropneumoniae. FEMS Microbiology Letters, 2017 Jul 3;364(12).

8. Zheng C, Ren S, Xu J, Zhao X, Shi G, Wu J, Li J, Chen H, Bei W*. Contribution of NADH oxidase to oxidative stress tolerance and virulence of Streptococcus suis serotype 2. VIRULENCE, 2016, 17:1-13.

9. Liu J, Hu L, Xu Z, Tan T, Yuan F, Fu S, Cheng H, Chen H, Bei W*. Actinobacillus pleuropneumoniae two-component system QseB/QseC regulates the transcription of PilM, an important determinant of bacterial adherence and virulence. Veterinary Microbiology, 2015, 177(1-2):184-192.

10. Yuan F, Liao Y, You W, Liu Z, Tan Y, Zheng C, Wang B, Zhou D, Tian Y*, Bei W*. Deletion of the znuA virulence factor attenuates Actinobacillus pleuropneumoniae and confers protection against homologous or heterologous strain challenge. Veterinary Microbiology, 2014, 174(3-4):531-539.

Patent

1) Construction and use of a genetic engineering Actinobacillus pleuropneumoniae serotype 7 double mutant strain which can be differentiated infected from vaccinated animals. Patent No.ZL200710052792.7, 26/01/2011, China.

2) Construction and use of a marker-free genetic engineering double mutant strain of Actinobacillus pleuropneumoniae serotype 1.Patent No.ZL200710051389.2, 11/02/2009, China.

3) Construction and use of a gene-deleted vaccine of Streptococcus suis double mutant strain. Patent No.ZL201110122342.7, China.

Note

He has been a reviewer for more than 10 international SCI journals including Vaccine, Analytica Chimica Acta, Comparative Immunology, Microbiology & Infectious Diseases. He participated in the compilation of three books including Veterinary Laboratory Diagnosis, Veterinary Manual and Genomics. He is an assessment expert of Natural Science Foundation Program ( NSFC), as well as NFSC of Beijing, Zhejiang and Jiangxi Province, and also an assessment expert of doctoral dissertations in the degree center of the Ministry of Education. From September 2016 to now, as the school-enterprise cooperation expert of Huazhong Agricultural University and Guangxi Yangxiang Co., Ltd., he is responsible for the establishment of biological safety management system in pig farms, as well as the prevention and control of major diseases.