CURRENT POSITION
Title: Professor, Molecular Virology/Veterinary Medicine
State Key Laboratory of Agricultural Microbiology
College of Veterinary Medicine
Huazhong Agricultural University, Wuhan, P. R. China 430070
E-mail: hbzhou@mail.hzau.edu.cn
EDUCATION
2006 Doctor’s degree, Molecular Virology/Veterinary Medicine
Huazhong Agricultural University, Wuhan, PR China
2003 Master’s degree of Veterinary Medicine
Huazhong Agricultural University, Wuhan, PR China
2000 Bachelor’s degree of Veterinary Medicine
Huazhong Agricultural University, Wuhan, PR China
PROFESSIONAL EXPERIENCE
2013-present Professor, College of Veterinary Medicine,
Huazhong Agricultural University, Wuhan, P. R. China
2011-2013 Postdoctoral Fellow, in Professor Wendy Barclay’s lab,
Imperial College London, London, UK
2008-2011 Associate Professor, College of Veterinary Medicine,
Huazhong Agricultural University, Wuhan, P. R.China
2006-2008 Postdoctoral Fellow, State Key Laboratory of Agricultural Microbiology,
Huazhong Agricultural University, Wuhan, P. R. China
RESEARCH INTERESTS
His current research aims at understanding the molecular pathogenic and cross-species infectious mechanism of influenza A virus, the interaction between influenza virus and host cells and developing the vaccine, diagnosis methods and antiviral drugs for animal influenza.
RESEARCH GRANTS
As Principle Investigator
2018-2020 Discovery and characterization of swine host factors required to support swine influenza virus replication. Hongbo Zhou (PI). National Natural Science Foundation of China (NSFC-RCUK_BBSRC) # 31761133005, ¥ 2,550,000
2018-2021 The study on molecular mechanism of nucleolar protein LYAR regulating influenza virus replication. Hongbo Zhou (PI). National Natural Science Foundation of China # 31772752, ¥ 600,000
2016-2020 Genetic Variation and Pathogenesis Mechanism of Animal Influenza Virus. Hongbo Zhou (PI). National Key Research and Development Program # 2016YFD0500205, ¥ 1,550,000
2016-2020 Study on the Occurrence and Spreading Mechanism of Important Emerging Pathogens. Hongbo Zhou (PI). National Key Research and Development Program # 2016YFC1200201, ¥ 450,000
2016-2019 Study on Molecular Mechanism of Nuclear Export Protein of Influenza Virus on Regulation of Viral vRNA, cRNA and mRNA Synthesis. Hongbo Zhou (PI). National Natural Science Foundation of China # 31572545, ¥ 768,000
2016-2018 Study on Screening and Function of Host Factors Affecting Swine Influenza Virus Replication. Hongbo Zhou (PI). The Outstanding Youth Science Foundation of Hubei Province # 2016CFA056, ¥ 200,000
2015-2017 Development of Key Technologies for Prevention and Control of Epidemic Diseases in Large - scale Chicken Farms. Hongbo Zhou (PI). The Major Scientific and Technological Innovation Projects of Hubei Province # 2015ABA039, ¥ 250,000
2015-2017 Establishment and Application of Detection Method on H9 Subtype Avian Influenza Virus. Hongbo Zhou (PI). The Youth Chenguang Project of Science and Technology of Wuhan # 2015070404010179, ¥100,000
2011-2013 Molecular Mechanism of Virulence Variation and Pathogenicity of H1 Subtype Swine Influenza Virus. Hongbo Zhou (PI). National Natural Science Foundation of China # 31072154, ¥ 350,000
2009-2011 Study on Recombination Mechanism of Pandemic H1N1/2009 Influenza Virus. Hongbo Zhou (PI). National Program on Key Basic Research Project (973 Program # 2010CB534002), ¥ 2,850,000
2009-2011 Effect of Amino Acids Deletion of NA Stalk and NS1 eIF4GI Binding Domain on Virulence and Pathogenicity of H5N1 Influenza A Virus. Hongbo Zhou (PI). National Natural Science Foundation of China # 30800832, ¥ 200,000
SELECTED PUBLICATIONS (* Corresponding author)
1. Wang R, Zhu Y, Ren C, Yang S, Tian S, Chen H, Jin M, Zhou H*. Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy. Autophagy. 2020 Feb 11:1-16.
2. Yang C, Liu X, Cheng T, Xiao R, Gao Q, Ming F, Jin M, Chen H, Zhou H*. LYAR Suppresses Beta Interferon Induction by Targeting Phosphorylated Interferon Regulatory Factor 3. J Virol. 2019 Oct 15;93(21). pii: e00769-19.
3. Wang R, Zhu Y, Lin X, Ren C, Zhao J, Wang F, Gao X, Xiao R, Zhao L, Chen H, Jin M, Ma W*, Zhou H*. Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production. Autophagy. 2019 Jul;15(7):1163-1181.
4. Wang R, Zhu Y, Zhao J, Ren C, Li P, Chen H, Jin M, Zhou H*. Autophagy Promotes Replication of Influenza A Virus In Vitro. J Virol. 2019 Feb 5;93(4). pii:e01984-18.
5. Ming F, Cheng Y, Ren C, Suolang S*, Zhou H*. Development of a DAS-ELISA for detection of H9N2 avian influenza virus. J Virol Methods. 2019 Jan;263:38-43.
6. Yang C, Liu X, Gao Q, Cheng T, Xiao R, Ming F, Zhang S, Jin M, Chen H, Ma W*, Zhou H*. The Nucleolar Protein LYAR Facilitates Ribonucleoprotein Assembly of Influenza A Virus. J Virol. 2018 Nov 12;92(23). pii: e01042-18.
7. Wei X, Qian W, Sizhu S, Li Y, Guo K, Jin M, Zhou H*. Negative Regulation of Interferon-β Production by Alternative Splicing of Tumor Necrosis Factor Receptor-Associated Factor 3 in Ducks. Front Immunol. 2018 Mar 1;9:409.
8. Guo K, Lin X, Li Y, Qian W, Zou Z, Chen H, Zhou H*, Jin M*. Proteomic analysis of chicken embryo fibroblast cells infected with recombinant H5N1 avian influenza viruses with and without NS1 eIF4GI binding domain. Oncotarget. 2017 Dec 22;9(9):8350-8367.
9. Zhang S, Wang R, Su H, Wang B, Sizhu S, Lei Z, Jin M, Chen H, Cao J, Zhou H*. Sus scrofa miR-204 and miR-4331 Negatively Regulate Swine H1N1/2009 Influenza A Virus Replication by Targeting Viral HA and NS, Respectively. Int J Mol Sci. 2017 Apr 3;18(4). pii: E749.
10. Wei X, Wang Y, Luo R, Qian W, Sizhu S*, Zhou H*. Identification and characterization of a protective antigen, PlpB of bovine Pasteurella multocida strain LZ-PM. Dev Comp Immunol. 2017 Jun;71:1-7.
11. Li Y, Ming F, Huang H, Guo K, Chen H, Jin M, Zhou H*. Proteome Response of Chicken Embryo Fibroblast Cells to Recombinant H5N1 Avian Influenza Viruses with Different Neuraminidase Stalk Lengths. Sci Rep. 2017 Jan 12;7:40698.
12. Wei X, Qian W, Sizhu S, Shi L, Jin M, Zhou H*. Molecular cloning and functional analysis of the duck TIR domain-containing adaptor inducing IFN-β (TRIF) gene. Dev Comp Immunol. 2016 Dec;65:369-376.
13. Zhao L, Zhu J, Zhou H*, Zhao Z, Zou Z, Liu X, Lin X, Zhang X, Deng X, Wang R, Chen H, Jin M*. Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells. Sci Rep. 2015 Oct 9;5:14991.
14. Zhang Y, Zhu J, Li Y, Bradley KC, Cao J, Chen H, Jin M, Zhou H*. Glycosylation on hemagglutinin affects the virulence and pathogenicity of pandemic H1N1/2009 influenza A virus in mice. PLoS One. 2013 Apr 24;8(4):e61397.
15. Zhang Y, Wang N, Cao J, Chen H, Jin M, Zhou H*. Genetic characterization of H1N2 swine influenza virus isolated in China and its pathogenesis and inflammatory responses in mice. Arch Virol. 2013 Sep;158(9):1965-72.
16. Zhou H, Wang C, Yang Y, Guo X, Kang C, Chen H, Jin M. Pandemic (H1N1) 2009 virus in swine herds, People's Republic of China. Emerg Infect Dis. 2011 Sep;17(9):1757-9.
17. Li Y#, Zhou H#, Wen Z, Wu S, Huang C, Jia G, Chen H, Jin M. Transcription analysis on response of swine lung to H1N1 swine influenza virus. BMC Genomics. 2011 Aug 8;12:398.
18. Zhou H, Zhang A, Chen H, Jin M. Emergence of novel reassortant H3N2 influenza viruses among ducks in China. Arch Virol. 2011 Jun;156(6):1045-8.
19. Zhou H, Zhu J, Tu J, Zou W, Hu Y, Yu Z, Yin W, Li Y, Zhang A, Wu Y, Yu Z, Chen H, Jin M. Effect on virulence and pathogenicity of H5N1 influenza A virus through truncations of NS1 eIF4GI binding domain. J Infect Dis. 2010 Nov 1;202(9):1338-46.
20. Zhou H, Yu Z, Hu Y, Tu J, Zou W, Peng Y, Zhu J, Li Y, Zhang A, Yu Z, Ye Z, Chen H, Jin M. The special neuraminidase stalk-motif responsible for increased virulence and pathogenesis of H5N1 influenza A virus. PLoS One. 2009 Jul 17;4(7):e6277.
21. Tu J#, Zhou H#, Jiang T, Li C, Zhang A, Guo X, Zou W, Chen H, Jin M. Isolation and molecular characterization of equine H3N8 influenza viruses from pigs in China. Arch Virol. 2009;154(5):887-90.
22. Zhou H, Jin M, Yu Z, Xu X, Peng Y, Wu H, Liu J, Liu H, Cao S, Chen H. Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and mice. Antiviral Res. 2007 Nov;76(2):186-93.
23. Zhou H, Jin M, Chen H, Huang Q, Yu Z. Genome-sequence analysis of the pathogenic H5N1 avian influenza A virus isolated in China in 2004. Virus Genes. 2006 Feb;32(1):85-95.
AWARDS
1. Meilin Jin, Huanchun Chen, Qigai, He, Bin Wu, Shihua Qi, Liurong Fang, Anding Zhang, Hongbo Zhou, Xuwang Cai, Gaoyuan Xu: China Major Swine Diseases Prevention and Control Innovation and Integrated Application. National Award for Science and Technology Progress, the second prize. December 21, 2016.
2. Meilin Jin, Huanchun Chen, Hongbo Zhou, Anding Zhang, Ying Yang, Gaoyuan Xu, Xiangmin Li, Bin Wu, Chao Kang, Zhong Zou, Xiaomei Sun, Xiaohui Dong, Zhangbiao Chen, Hanbing Dan: Pathogenic Mechanism and Prevention and Control of Swine Influenza Virus. Hubei Provincial Award for Science and Technology Progress, the first prize. August 31, 2015.
3. Meilin Jin, Huanchun Chen, Bin Wu, Anding Zhang, Hongbo Zhou, Bogen Qiu, Nianhua Song, Xiaojuan Xu, Xuebo Guo, Hanbing Dan: Fast Detection of Animal Influenza Viruses and its Application. National Award for Science and Technology Progress, the second prize. December 23, 2011.
