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Z
赵凌
发布人:发布时间:2020-03-16

职称 教授

学位 博士

政治面貌 农工党党员

电话 027-87285016

邮箱 lingzhao@mail.hzau.edu.cn

研究方向 预防兽医学


教育背景

1996.09 - 2000.06 华中农业大学,兽医专业,农学学士

2000.09 - 2003.06 华中农业大学,预防兽医学,农学硕士

2004.09 - 2009.08 美国佐治亚大学,兽医病毒学,博士


工作经历

2012.08-至今,华中农业大学, 动科-动医学院, 教授、博士生导师


研究领域

狂犬病毒致病与免疫机制、新型疫苗、佐剂与诊断制剂。


科研成果

A著作类

1.Handbook of nucleic acid purification 参编

2. 《犬猫传染病》参编

B论文类

1. Yuan Y, Wang Z, Tian B, Zhou M, Fu ZF, Zhao L* Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.Arch Virol. 2019 Dec;164(12):2963-2974. doi: 10.1007/s00705-019-04415-6.

2. Pei J, Huang F, Wu Q, Luo Z, Zhang Y, Ruan J, Li Y, Zhou M, Fu Z, Zhao L*.Codon optimization of G protein enhances rabies virus-induced humoral immunity. J Gen Virol. 2019 Aug;100(8):1222-1233. doi: 10.1099/jgv.0.001299. Epub 2019 Jul 1.

3. Luo Z, Li Y, Zhou M, Lv L, Wu Q, Chen C, Zhang Y, Sui B, Tu C, Cui M, Chen H, Fu ZF, Zhao L*. 2019. Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers. Front Immunol. 2019 Mar 8;10:429. doi: 10.3389/fimmu.2019.00429.

4. Chen C, Zhou M, Yan XG, Chen YX, Cui M, Chen HC, Fu ZF, Zhao L*.2019. A recombinant canine distemper virus expressing interleukin-7 enhances humoral immunity. J Gen Virol. 2019 Apr;100(4):602-615. doi: 10.1099/jgv.0.001247.

5. Tian B, Zhou M, Yang Y, Yu L, Luo ZC, Tian DY, Wang K, Cui M, Chen HC, Fu ZF*, Zhao L*. 2018. Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway. Front Immunol. 2018 Jan 19;8:2011. doi: 10.3389/fimmu.2017.02011.

6. Xia L, Li M, Zhang Y, Ruan J, Pei J, Shi J, Fu ZF, Zhao L, Zhou M, Tian D.2018. Exhaustive Exercise Does Not Affect Humoral Immunity and Protection after Rabies Vaccination in a Mouse Model.Virol Sin. 2018 Jun; 33(3):241-248. doi:10.1007/s12250-018-0026-1.

7. Zhao Wang, Qian Liang, Yajing Zhang, Jie Yang, Mingming Li, Kunlun Wang, Min Cui, Huanchun Chen, Zhen F. Fu, Ling Zhao*, Ming Zhou*. 2017. An optimized HMGB1 expressed by recombinant rabies virus enhances immunogenicity through activation of dendritic cells in mice. Oncotarget doi:10.18632/oncotarget.18368.

8. Chen T, Zhang Y, Wang Z, Yang J, Li M, Wang K, Cui M, Fu ZF, Zhao L*, Zhou M*. 2017. Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice. Virol Sin 32:317-327.

9. Wang Z, Li M, Zhou M, Zhang Y, Yang J, Cao Y, Wang K, Cui M, Chen H, Fu ZF, Zhao L*. 2017. A Novel Rabies Vaccine Expressing CXCL13 Enhances Humoral Immunity by Recruiting both T Follicular Helper and Germinal Center B Cells. J Virol 91.

10. Li Y, Zhou M, Luo Z, Zhang Y, Cui M, Chen H, Fu ZF, Zhao L*. 2017. Overexpression of IL-7 extends the humoral immune response induced by rabies vaccination. J Virol doi:10.1128/JVI.02324-16.

11. Zhang Y, Zhou M, Wang Z, Yang J, Li M, Wang K, Cui M, Chen H, Fu ZF, Zhao L*. 2016. Recombinant rabies virus expressing IL-21 enhances immunogenicity through activation of T follicular helper cells and germinal centre B cells. J Gen Virol 97:3154-3160.

12. Tian D, Luo Z, Zhou M, Li M, Yu L, Wang C, Yuan J, Li F, Tian B, Sui B, Chen H, Fu ZF, Zhao L*. 2016. Critical Role of K1685 and K1829 in the Large Protein of Rabies Virus in Viral Pathogenicity and Immune Evasion. J Virol 90:232-244.

13. Sui B, Huang J, Jha BK, Yin P, Zhou M, Fu ZF, Silverman RH, Weiss SR, Peng G, Zhao L*. 2016. Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. J Gen Virol doi:10.1099/jgv.0.000395.

14. Navid MT, Li Y, Zhou M, Cui M, Fu ZF, Tang L, Zhao L*. 2016. Comparison of the immunogenicity of two inactivated recombinant rabies viruses overexpressing the glycoprotein. Arch Virol 161:2863-2870.

15. Zhou M WL, Zhou S, Wang Z, Ruan J, Tang L, Jia Z, Cui M, Zhao L*, Fu ZF*. 2015. Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs. Oncotarget

16. Luo Z, Tian D, Zhou M, Xiao W, Zhang Y, Li M, Sui B, Wang W, Guan H, Chen H, Fu ZF, Zhao L*. 2015. lambda-Carrageenan P32 Is a Potent Inhibitor of Rabies Virus Infection. PLoS One 10:e0140586.

17. Zhao L, Birdwell LD, Wu A, Elliott R, Rose KM, Phillips JM, Li Y, Grinspan J, Silverman RH, Weiss SR. 2013. Cell-Type-Specific Activation of the Oligoadenylate Synthetase-RNase L Pathway by a Murine Coronavirus. J Virol 87:8408-8418.

18. Zhao L, Jha BK, Wu A, Elliott R, Ziebuhr J, Gorbalenya AE, Silverman RH, Weiss SR. 2012. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell Host Microbe 11:607-616.

19. Zhao L, Rose KM, Elliott R, Van Rooijen N, Weiss SR. 2011. Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus. J Virol 85:10058-10068.

20. Zhao L, Toriumi H, Wang H, Kuang Y, Guo X, Morimoto K, Fu ZF. 2010. Expression of MIP-1alpha (CCL3) by a recombinant rabies virus enhances its immunogenicity by inducing innate immunity and recruiting dendritic cells and B cells. J Virol 84:9642-9648.

21. Zhao L, Toriumi H, Kuang Y, Chen H, Fu ZF. 2009. The roles of chemokines in rabies virus infection: overexpression may not always be beneficial. J Virol 83:11808-11818.


科研项目 

1.狂犬病病毒mRNA加帽酶对病毒致病性和免疫逃避的影响, 国家自然科学基金(面上项目), 2014-2017

2. 兽医传染病学, 国家自然科学基金(优青), 2016-2018

3.重要神经嗜性人兽共患病免疫与致病机制研究-病原诱导天然免疫应答及其调控机制研究, 国家重点研发计划子课题,2016-2020


主要奖励

1.2014年入选“3551光谷人才计划”

2.2015年获国家自然科学基金“优秀青年科学基金”资助

3.2016年获“武汉市优秀青年科技工作者


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