华中农业大学农业微生物学国家重点实验室欢迎您!

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Z
张宏宇
发布人:发布时间:2020-03-17


职称 教授

学位 博士

政治面貌 中共党员

电话 027-87286962

邮箱 hongyu.zhang@mail.hzau.edu.cn

研究方向 昆虫分子生物学与微生物学;害虫综合防治(特别害虫的绿色防控技术,如遗传防治、生物防治)


教育经历

1982.09-1986.06 湖南农业大学 学士 植物保护

1988.09-1991.06 华中农业大学 硕士 农业昆虫与害虫防治

1995.09-1998.06 华中农业大学 博士 微生物


主要职历

1991.07-1998.07 华中农业大学植科院,讲师

1998.07-2001.07 华中农业大学植科院,副教授

1999.03-1999.11 以色列农业研究中心,访问学者

2001.07-2002.08 德国康斯坦茨大学,博士后

2002.09-2004.08 新西兰农业研究院,博士后研究员

2005.05-2005.08 美国密歇根州立大学,高级访问学者

2013.08-2014.02 美国佛罗里达大学,高级访问学者

2004-2018  华中农业大学植物科学技术学院,教授,农业微生物国家重点实验室和国家微生物农药工程中心(昆虫微生物及其微生物农药创新团队)

2019至今 华中农业大学植物科学技术学院,二级教授


科研成果

科研方向

1. 昆虫微生物组。主要研究昆虫病原与共生微生物组及其与宿主昆虫互作、协调进化规律;昆虫病原与共生微生物遗传改造与微生物农药研发。

2. 害虫发育繁殖行为、免疫的分子机理研究与转基因昆虫研究。

3. 园艺与城市害虫绿色防控技术及智能化信息与专家系统研发。


学术成绩

长期从事昆虫微生物组与发育繁殖等分子机制及害虫绿色防控技术的研究,发表SCI论文近100篇。近5年来的研究工作主要集中在实蝇性别分化、发育繁殖和免疫的分子机制及与共生微生物的互作机制方面:系统研究了橘小实蝇肠道微生物多样性、群落组成及其功能与稳态调控(The ISME Journal, 2016; Plos pathogens, 2020);建立橘小实蝇RNAiCRISPR/Cas9基因编辑技术平台并以此为基础阐明发育繁殖与免疫重要基因的功能,阐明了实蝇性别调控的分子机制,明确及其性别决定关键基因(tra)和miRNA的功能(Nature Communications2020),为转基因品系构建奠定了基础;阐明脂肪酸合成与代谢通路调控橘小实蝇对RNAi的免疫耐受机制。此外,积极研发害虫绿色防控技术:国际上首次成功发现了柑橘大实蝇的性信息素,研发高效饵剂、理化一体灯等新型诱捕器,并建立了田间应用技术;建立木虱LED灯和色板诱杀技术、高效饵剂和驱避剂及其推-拉技术和科学精准用药技术;座壳孢菌、玫烟色棒束孢等木虱、粉虱病原微生物资源挖掘、剂型化与微生物农药研制及其田间应用技术。江原钝绥螨等天敌扩繁与释放技术,获批国家发明专利10项,实用新型3项。


10年主持的主要科研项目

1. 国家现代农业(柑橘)产业体系(MATS)创新岗位(危险性害虫),2007至今。

2. 重点研发计划“长江中游柑橘化肥农药减施技术集成研究与示范(No.2017YFD0202003),课题主持人,2017-2021

3. 国家自然科学基金“IMD通路负调控基因在橘小实蝇肠道微生物群落稳态调控中的功能研究”(No.31572008),2016-2019

4. 国家自然科学基金“橘小实蝇肠道IMD/Duox-ROS免疫互作分子机制研究” (No. 31872931),2019-2022

5. 联合国粮农组织/国际原子能署(FAO/IAEA)项目“Fitness Improvement of Mass-Reared Sterile Males of Bactrocera dorsalis and Bactrocera minax Through their Symbionts”(No. I8801),2015-2020

6. 国家自然科学基金项目“暗黑鳃金龟肠道细菌宏基因组及其在纤维素代谢中的功能研究”,2013-2016。已结题

7. 国家公益性行业(农业)科研专项“果树实蝇类害虫防控示范技术研究”专题,2009-2013。已结题

8. 国家公益性行业(农业)科研专项“捕食螨繁育与大田应用技术研究”专题,2009-2013。已结题

9. 国家“十一五”科技支撑计划子专题“农村储粮专用新型防护剂药剂的开发”,2007-2010。已结题

10. 国家“十一五”科技支撑计划子专题 “玄参重要病虫生物学及无害化治理集成技术研究”,2006-2010。已结题

11. 国家自然科学基金项目“金龟子肠道共生微生物分子多态性及其功能研究”,2007-2009。已结题


代表性学术论文

1. Peng W., Yu S.N., Alfred M. H., Tu Z.J. , Giuseppe S. , Xi Z.Y. Zhang H.Y. *2020. miRNA-1-3p is an early embryonic male sex-determining factor in the Oriental fruit fly Bactrocera dorsalis. Nat Commun 11, 932.https://doi.org/10.1038/s41467-020-14622-4 (通讯作者)

2. Yao Z.C., Wang A.L., Li Y.S., Cai Z.H., Lemaitre B., Zhang, H.Y.*. 2016. The dual oxidase gene BdDuox regulates the intestinal bacterial community homeostasis of Bactrocera dorsalis. ISME J. ,10(5):1037-1050 (通讯作者)

3. Muhammad F. R., Wang Y.C., Cai Z.H., Bai Sh., Yao Z.C., Umar A.A., Zhang Z.Y., Zheng W.W., Zhang H.Y. 2020a. Gut microbiota promotes host resistance to low-temperature stress by stimulating its arginine and proline metabolism pathway in adult Bactrocera dorsalis. PLoS Pathogens https://doi.org/10.1371/journal.ppat.1008441. (通讯作者)

4. Yao Z.C.,Ma Q.K.,Cai Z.H., Muhammad F. R.,Bai S.,Wang Y.C., Zhang P.,Ma H.Q.,Zhang H.Y.*, 2019. Similar Shift Patterns in Gut Bacterial And Fungal Communities Across the Life Stages of Bactrocera minax Larvae From Two Field Populations. Frontiers in Microbiology,(2019) 10:2262, doi: 10.3389/fmicb.2019.02262 (通讯作者)

5. Peng W.,Zheng W.W.,Tariq K.,Yu S.N.,Zhang H.Y.*, 2019. MicroRNA Let-7 targets the ecdysone signaling pathway E75 gene to control larval-pupal development in Bactrocera dorsalis. Insect Sci,(2019) 26, 229–239, DOI 10.1111/1744-7917.12542 (通讯作者)

6. Zheng W.P., Li Q.M., Sun H., Muhammad W.A., Zhang H.Y*, 2019. CRISPR/Cas9-mediated mutagenesis of the mew gene induces muscle weakness and flightlessness in Bactrocera dorsalis (Diptera: Tephritidae). Insect Molecular Biology. (2019) 28(2), 222–234 (通讯作者)

7. Meng L.X., LI X.Y., Cheng X.Q., Zhang H.Y.*, 2019. 16S rRNA Gene Sequencing Reveals a Shift in the Microbiota of Diaphorina citri During the Psyllid Life Cycle. Frontiers in Microbiology, (2019) 10:1948.DOI 10.3389/fmicb.2019.01948(通讯作者)

8. Cai Z.H., Yao Z.C., Li Y.S., Xi Z.Y., Bourtzis K., Zhao Z., Bai S., Zhang H.Y.*, 2018. Intestinal probiotics restore the ecological fitness decline of Bactrocera dorsalis by irradiation. Evolutionary Applications. 2018; 1–18. (通讯作者)

9. Meng L.X., Wang Y.M., Wei W.H., Zhang H.Y.*, 2018.Population genetic structure of Diaphorina citri Kuwayama (Hemiptera: Liviidae): host-driven genetic differentiation in China. Scientific Reports.2018,|8:1473| DOI:10.1038/s41598-018-19533-5(通讯作者)

10. Tariq K.,Noor M.,Hussain A.,Ali A,.Peng W.,Zhang H.Y.*,2017.The toxicity of flonicamid to cotton leafhopper, Amrasca biguttula (Ishida), is by disruption of ingestion: an electropenetrography study. Pest Management Science,2017,73(8):1661-1669.Doi:10.1002/ps.4508. (通讯作者)

11. Muhammad W.A.,Zhang Z.Y.,Xia S.,& Zhang H.Y.*. 2017. Biofunctional analysis of Vitellogenin and Vitellogenin receptor in citrus red mites, Panonychus citri by RNA interference.Scientific Reports.2017,7(1)|7:16123|DOI:10.1038/s41598-017-16331-3(通讯作者)

12. Tariq K.,Noor M.,Hori M.,Ali A., Peng W.,and Zhang H.Y.*, 2017. Blue light-induced immunosuppression in Bactrocera dorsalis adults, as a carryover effect of larval exposure. Bulletin of Entomological Research,2017,107(6):734-741. Doi:10.1017/S0007485317000438. (通讯作者)

13. Muhammad W.A., Zheng W.P., Sohail S., Li Q. M., Zheng W.W.& Zhang H.Y.*, 2017. A genetically enhanced sterile insect technique against the fruit fly, Bactrocera dorsalis (Hendel) by feeding adult double-stranded RNAs. Scientific Reports.2017,7(1)|7:4063| DOI:10.1038/s41598-017-04431-z (通讯作者)

14. Dong X.L.,Li X.X.,Li Q.J.,Jia H.M.& Zhang H.Y.*,2017.The inducible blockage of RNAi reveals a role for polyunsaturated fatty acids in the regulation of dsRNA-endocytic capacity in Bactrocera dorsalis.Scientific Reports.2017,7(1)|7:5584|DOI:10.1038/s41598-017-05971-0(通讯作者)

15. K. Tariq, M. Noor, M. Hori, A. Ali, A. Hussain,W. Peng, C.-J. Chang and Zhang H. Y.*2017. Blue light-induced immunosuppression in Bactrocera dorsalis adults, as a carryover effect of larval exposure. Bulletin of Entomological Research. doi:10.1017/S0007485317000438. (通讯作者)

16. Tariq K., Metzendorf C., Peng W., Sohail S., Zhang H.Y.*. 2016. miR-8-3p regulates mitoferrin in the testes of Bactrocera dorsalis to ensure normal spermatogenesis. Scientific Reports. 6:22565 | DOI: 10.1038/srep22565(通讯作者)

17. Peng, W., Tariq, K., Xie, J.F., Zhang,H.Y.*, 2016. Identification and Characterization of Sex-Biased MicroRNAs in Bactrocera dorsalis (Hendel). Plos. One. 117. DOI:10.1371/journal.pone.0159591(通讯作者)

18. Li Q.J., Dong X.L., Zheng W.W., Zhang H.Y.*, 2016. The PLA2 gene mediates the humoral immune responses in Bactrocera dorsalis (Hendel). Developmental and Comparative Immunology, 67: 293-299. http://dx.doi.org/10.1016/j.dci.2016.09.006(通讯作者)

19. Zheng W.W.* , Luo D.Y., Wu F.Y., Wang J.L., Zhang H.Y.*. 2016. RNA sequencing to characterize transcriptional changes of sexual maturation and mating in the female oriental fruit fly Bactrocera dorsalis. BMC Genomics,17:194.DOI 10.1186/s12864-016-2532-6(通讯作者)

20. Tariq K., Peng W., Saccone G., Zhang H.Y.*. 2016. Identification, characterization and target gene analysis of testicular microRNAs in the oriental fruit fly Bactrocera dorsalis. Insect Molecular Biology. 25(1), 32–43. doi: 10.1111/imb.12196(通讯作者)

21. Li, X.X., Dong, X.L., Zou, C., Zhang, H.Y.*. 2015. Endocytic pathway mediates refractoriness of insect Bactrocera dorsalis to RNA interference. Scientific reports. 5:8700(通讯作者)

22. Tariq K., Noor M. ,Saeed S., Zhang H.Y.*. 2015. The Effect of Ultraviolet-A Radiation Exposure on the Reproductive Ability, Longevity, and Development of the Dialeurodes citri (Homoptera: Aleyrodidae) F1 Generation. Environ. Entomol. 44(6): 1614–1618; DOI: 10.1093/ee/nvv133(通讯作者)

23. Dong X. L., Li Q.J., Zhang H.Y.*. 2015. The noa gene is functionally linked to the activation of the Toll/Imd signaling pathways in Bactrocera dorsalis (Hendel). Developmental and Comparative Immunology. 55, 233-240. (通讯作者)

24. Chen A.E., Zheng W.W., Zheng W.P., Zhang H.Y.*. 2015. The effects of RNA interference targeting Bactrocera dorsalis ds-Bdrpl19 on the gene expression of rpl19 in non-target insects. Ecotoxicology. 24:595–603(通讯作者)

25. Giuseppe S.*, Christos L., Zhang H.Y.*. Valeria P., Manuela Di N. , Maria P., Marco S. mini. 2014. Male-specific phosphorylated SR proteins in adult flies of the Mediterranean Fruitfly Ceratitis capitata. BMC Genetics. 15(Suppl 2):S6(通讯作者)

26. Wang H.X., Jin L. Peng T., Zhang H.Y.*, Chen Q.L. and Hua Y.J. 2014.Identification of cultivable bacteria in the intestinal tract of Bactrocera dorsalis from three different populations and determination of their attractive potential. Pest Manag Sci, 70:8087. (通讯作者)

27. Sheng P., Xu J., Saccone G., Li K.B., Zhang H.Y. *,2014. Discovery and characterization of endo-xylanase and β-xylosidase from a highly xylanolytic bacterium in the hindgut of Holotrichia parallela larvae. J Mol Catal B-Enzym. 105, 33-40 (通讯作者)

28. Wang P.P., Song X.H., Zhang H.Y.*. 2013. Isolation and characterization of Aschersonia placenta from citrus orchards and its pathogenicity towards Dialeurodes citri(Ashmead). Journal of Invertebrate Pathology. 112:122–128(通讯作者)

29. Chen H.L., Zhang H.Y.*. Zhu k.y., Throne J.*. 2013. Performance of diapausing parasitoid wasps, Habrobracon hebetor, after cold storage. Biological Control. 64: 86–194(通讯作者)

30. Zheng W. W., Zhu Ch P., Peng T., Zhang H.Y.*.2012. Odorant receptor co-receptor Orcois upregulated by methyl eugenol in male Bactrocera dorsalis (Diptera: Tephritidae). Journal of Insect Physiology 58:1122–1127(通讯作者)

31. Li X.X., Zhang M.Y., Zhang H.Y.*, 2011, RNA interference of four genes in adult Bactrocera dorsalis by feeding their dsRNAs. PLoS One, 6(3):e17788 , doi: 10.1371/journal.pone.0017788(通讯作者)

32. Wang H.X., Jin L., Zhang H.Y.*, 2011, Comparison of the diversity of the bacterial communities in the intestinal tract of adult Bactrocera dorsalis from three different populations. Journal of Applied Microbiology, 110(6): 1390-1401(通讯作者)

33. Chen H. L., Opit G. P., Sheng P. and Zhang H.Y.*.2011. Maternal and Progeny Quality of Habrobracon hebetor Say (Hymenoptera: Braconidae) After Cold Storage. Biological Control, 58, 255-261. (通讯作者)

34. Zhang H.Y.*, and Jackson T. , Microbial diversity in the alimentary tract of Costelytra zealandica (Coleoptera: Scarabaeidae) larvae by PCR-DGGE of 16S rRNA gene fragments. Journal of Applied microbiology, 2008,105(5): 1277-1285(第一作者)

35. Zhang H.Y.*, and Brune A., Characterization and partial purification of proteinases from the highly alkaline midgut of the humivorous larvae of Pachnoda ephippiata (Coleoptera: Scarabaeidae). Soil Biology & Biochemistry, 2004, 36: 435–442(第一作者)

36. Zhang H.Y.*, Yang C.J., Huang J.Y. Lü L., Susceptibility of field populations of Anopheles sinensis Wiedemann (Diptera: Culicidae) to Bacillus thuringiensis subsp. israelensis. Biocontrol Science and Technology, 2004,14(3): 321-325(第一作者)

37. Zhang H.Y.*, Zeng X.H., Yu Z.N. and Deng W.X., Characterization and toxicity of Bacillus thuringiensis isolates from warehouses to Spodoptera exigua (Lep., Noctuidae). Journal of Applied Entomology, 2001, 125: 211-214(第一作者)

 

授权发明专利及软件著作权

1. 国家发明专利,“一种桔形被毛孢油剂”,专利号ZL201611096778.2

2. 国家发明专利,“一种可降解农产品废弃物的复合微生物菌剂”,专利号ZL201610498520.9

3. 国家发明专利,“昆虫益生菌及饲料添加剂”,专利号ZL201610829621.X

4. 国家发明专利,“一种玫烟色棒束孢的发酵培养方法”,专利号ZL201611096775.9

5. 国家发明专利,“一种柑橘大实蝇性信息素”,专利号ZL201510543538.1

6. 国家发明专利:“一种座壳孢菌微胶囊悬浮剂及其制备方法”,专利号ZL201510247135.2

7. 国家发明专利:“一种江原钝绥螨的饲料及人工饲养方法”,专利号ZL201310168029.6

8. 国家发明专利:“一种扁座壳孢菌的规模化生产发酵培养基及发酵培养方法”,专利号ZL201410663655.7

9. 国家发明专利:“暗黑鳃金龟引诱剂及苯甲醚用作暗黑鳃金龟引诱剂的用途”,专利号ZL201310128868.5

10. 国家发明专利,“异常汉逊酵母菌在制备柑橘实蝇类引诱饵剂中的应用”,专利号ZL201210245822.7

11. 国家实用新型专利:“一种理化一体多功能杀虫装置”,专利号ZL201820177567.X

12. 国家实用新型专利:“一种实蝇类害虫诱杀装置”,专利号ZL201620011742.9

13. 国家实用新型专利,“一种柑橘象鼻虫诱卵装置”,专利号ZL201420768983.9

14. 2012年国家计算机软件著作权:柑橘虫害信息系统(简称:CPISV1.0(中华人民共和国国家版权局)

15. 2012年国家计算机软件著作权:实蝇专家咨询系统V1.0NO.00142708(中华人民共和国国家版权局)


备注

先后任International Foundation for Science科学顾问,中国粮油学会理事,中国植保学会园艺作物病虫害防治专业委员会委员,中国昆虫学会昆虫微生物组学专业委员会副主任委员和城市昆虫、药剂与毒理、外来物种及检疫专业委员会委员,湖北省植保学会副理事长。


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