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位灯国
发布人:发布时间:2021-03-23






姓名 位灯国

职称 教授

学位 博士

政治面貌 民盟盟员

邮箱dgwei@mail.hzau.edu.cn



教育经历

1998.09 - 2002.06 华中师范大学,理学学士

2002-09~2005-06 华中师范大学,理学硕士

2005-09~2009-06 北京大学,理学博士


工作经历

2009.10–2012.10,伦敦大学学院药学院,博士后;

2013.06-2015.05,于默奥大学化学生物学中心,博士后;

2015.06-至今,华中农业大学,教授


研究方向

研究方向:药物化学生物学、结构生物学、药物分子设计。

课题组综合应用结构生物学、分子生物学、生物物理化学和计算模拟等技术方法,研究有望成为药物靶点的蛋白和核酸,阐明它们致病的结构基础与分子机制;并在原子分辨率水平上,揭示药物靶点蛋白和核酸与配体(包括药物)的识别机制,结合计算模拟和药物合成,开展基于结构和基于疾病网络的农兽药小分子设计。

欢迎多个学科的本科生、研究生以及博士后来学习、工作。


科研项目

1. G-四链体结构去稳定剂的作用机制与设计研究, 国家自然科学基金面上项目 2021

2.伪狂犬病毒IE180 3'UTR区G-四链体结构及其在病毒复制中的作用,国家自然科学基金面上项目 2017

3. 基于生防菌代谢物作用机制及结构的生态农药创制,华中农业大学新进高层次人才科研启动项目 2015

4.靶向特殊核酸结构的农药分子设计, 华中农业大学自主创新基金  2015

5. 靶向G-四链体的抗肿瘤药物研究,华中农业大学自主创新基金  2017

6. 靶向C-kit1 DNA G-四链体凹槽的选择性探针分子设计 国家自然科学基金青年科学基金 2016


代表性论文

1.BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers. Chao Gao, Zhu LiuHaitao Hou, Jieqin Ding, Xin Chen, Congbao Xie, Zibing Song, Zhe Hu, Mingqian Feng, Hany I Mohamed, Shengzhen Xu *, Gary N Parkinson, Shozeb Haider *, Dengguo Wei *. Nucleic Acids Res. 2020;48(20):11259-11269. (IF=11.797

2.Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths Yashu Zhang, Kamel El-Omari, Ramona Duman, Sisi Liu, Shozeb M. Haider, Armin Wagner, Gary N. Parkinson *, Dengguo Wei * Nucleic Acids Res.; 2020;48(17):9886-9898. (IF=11.797

3.G2-quadruplex in the 3'UTR of IE180 Regulates Pseudorabies Virus Replication by Enhancing Gene Expression. Ya-Shu Zhang, Si-Si Liu, Hui Jiang , Hui Deng, Chen Dong, Wei Shen, Hai-Feng Chen, Chao Gao, Shao-Bo Xiao, Zheng-Fei Liu*, Dengguo Wei*; RNA Biol. 2020;17(6):816-827. IF=5.350, 被选为封面文章)

4.Specific recognition of telomeric multimeric G-quadruplexes by a simple-structure quinoline derivative. Jingfang ZhaoZiyanYangQianqianZhai*, Dengguo Wei*. Analytica Chimica Acta. 20201132: 93-100. IF=5.977

5.Virtual screening for triple-negative breast cancer cell inhibitors based on telomere G-quadruplex structure. Hua Deng, Chao Gao, Dengguo Wei*, Sisi Liu*. J. Chin. Pharm. Sci. 2020, 29 (6), 383389.

6.Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe. Qianqian Zhai, Chao Gao, Jieqin Ding, Yashu Zhang, Barira Islam, Wenxian Lan, Haitao Hou, Hua Deng, Jun Li, Zhe Hu, Hany I Mohamed, Shengzhen Xu, Chunyang Cao, Shozeb M Haider, and Dengguo Wei*. Nucleic Acids Res. 2019;47(5):2190-2204. (IF=11.797

7.Mechanism of the temperature-responsive material regulating porous morphology on epoxy phenolic novolac resin microcapsule surface. Xianpeng Zhang, Luxia Zhang, Daxia Zhang, Sisi Liu*, Dengguo Wei*, Feng Liu* Colloids and Surfaces A: Physicochemical and Engineering Aspects 2020 10.1016/j.colsurfa.2020.124581

8.Oligo(ethylene glycol)-Functionalized Ratiometric Fluorescent Probe for the Detection of Hydrazine in Vitro and in Vivo. Jun Li , Yuanchao CuiChenxi Bi, Shaoqiong Feng, Fengzhen Yu, En Yuan, Shengzhen Xu, Zhe Hu, Qi Sun*, Dengguo Wei*, Juyoung Yoon* Anal. Chem., 201991 (11), 7360-7365

9.Intensive Distribution of G-Quaduplexes in the Pseudorabies Virus Genome and Their Sensitivity to Cations and G-Quadruplex Ligands. Hui Deng, Bowen Gong, Zhiquan Yang, Zhen Li, Huan Zhou, Yashu Zhang, Xiaohui Niu, Sisi Liu*, and Dengguo Wei* Molecules. 2019; 24(4). pii: E774. doi: 10.3390/molecules24040774.

10.Flexibility and structural conservation in a c-KIT G-quadruplex. Dengguo Wei, Jarmila Husby and Stephen Neidle. Nucleic Acids Res. 2015, 43 (1):629-44            

11.Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined    dimer quadruplex. Dengguo Wei, Alan K. Todd, Mire Zloh, Mekala Gunaratnam, Gary N. Parkinson, and Stephen Neidle J. Am. Chem. Soc., 2013, 135 (51):1931929                

12.Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster. Dengguo Wei, W David Wilson and Stephen Neidle, J. Am. Chem. Soc. 2013, 135(4):1369-77                                        

13.Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop. Dengguo Wei, Gary N. Parkinson, Anthony P. Reszka and Stephen Neidle Nucleic Acids Res. 2012, 40(10):4691-700                  

14.Binding Energy Landscape Analysis Helps to Discriminate True Hits from High-Scoring Decoys in Virtual Screening. Dengguo Wei, Hao Zheng, Naifang Su, Minghua Deng and Luhua Lai J. Chem. Inf. Model., 2010, 50 (10), 185564        

15.Discovery of Multitarget Inhibitors by Combining Molecular Docking with Common Pharmacophore Matching. Dengguo Wei, Xiaolu Jiang, Lu Zhou, Jing Chen, Zheng Chen, Chong He, Kun Yang,Ying Liu, Jianfeng Pei and Luhua Lai, J. Med. Chem., 2008, 51 (24), 78828  

16.Binding Model Construction of Antifungal 2-Aryl-4-chromanones Using CoMFA, CoMSIA, and QSAR Analyses. Dengguo Wei, Guangfu Yang, Jian Wan and Changguo Zhan, J. Agric. Food Chem., 2005, 53 (5), 160411    

17.Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties. Yu-Xiu Liu, Dengguo Wei, Ye-Rong Zhu, Shao-Hua Liu, Yong-Lin Zhang, Qi-Qi Zhao, Bao-Li Cai, Yong-Hong Li, Hai-Bin Song, Ying Liu, Yong Wang, Run-Qiu Huang and Qing-Min Wang J. Agric. Food Chem. 2008, 56, 20412 (Contributed equally to the first author)          

18.Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis. Xiaolu Jiang, Lu Zhou, Yiran Wu, Dengguo Wei, Chunyi Sun, Jia Jia, Ying Liu and Luhua Lai Chembiochem. 2010 May 17; 11(8):1120-8

19.Controlling arachidonic acid metabolic network: from single- to multi-target inhibitors of key enzymes. Ying Liu, Zheng Chen, Er-chang Shang, Kun Yang, Dengguo Wei, Lu Zhou, Xiaolu Jiang, Chong He, Luhua Lai. Acta Pharmaceutica Sinica 2009, 44 (3): 23141

20.Resurveying the Tris buffer solution: the specific interaction between tris (hydroxymethyl) aminomethane and lysozyme. Li Quan, Dengguo Wei, Xiaolu Jiang, Yang Liu Zhiyu Li, Na Li, Kean Li, Feng Liu and Luhua Lai. Anal Biochem. 2008; 378(2):144-50.  

Activation and Inhibition of Leukotriene A4 Hydrolase Aminopeptidase Activity by Diphenyl Ether and Derivatives, Xiaolu Jiang, Lu Zhou, Dengguo Wei, Hu Meng, Ying Liu and Luhua Lai, Bioorg. med. lett. 2008; 18(24):6549-52.


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