华中农业大学农业微生物学国家重点实验室欢迎您!

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S
孙明
发布人:发布时间:2020-03-31

职称 教授

学位 博士

政治面貌 中共党员

电话 027-87283455

邮箱 m98sun@mail.hzau.edu.cn

研究方向 微生物农药


教育经历

1984.09-1988.07,武汉大学生物系微生物学专业,理学学士

1988.09-1991.06  华中农业大学微生物学专业, 理学硕士

1992.09-1995.12 华中农业大学微生物学专业,理学博士

 

主要工作和研究经历

1991.07-现在  华中农业大学土化系/生命科学技术学院 教授

1994. 05-1994.11 美国The Ohio State University生化系 访问学者

1997.06-1997.09 加拿大University of Waterloo化工系/生物系 UNISCO-ASM访问学者

1997.10-1998.10 新加坡Institute of Molecular Agrobiology 访问学者

2002.07-2003.01 美国Cornell University微生物系 高级访问学者

2004.05-2004.11  The University of Hong Kong生物多样性和生态学系, 裘搓Croucher访问学者

 

科研情况

科研方向

主要从事以苏云金芽胞杆菌为对象的微生物农药开发相关的基础和应用研究,以及植物寄生线虫的微生物防控及其相关生物学研究。


在研主持科研项目

1. 苏云金芽胞杆菌调控RNA的多样性研究,国家自然科学基金面上项目(31670085),2017/01-2020/12。

2. 高效广谱杀虫微生物株系筛选与定向改良,国家重点研发计划项目课题(2017YFD0201201), 2017/07-2020/12

3. IITA系统在苏云金芽胞杆菌侵染宿主中的功能和机制研究,国家自然科学基金面上项目(31970076), 2020/01-2023/12


代表性学术论文

1. Zheng Z, Zhang Y, Liu Z, Dong Z, Xie C, Bravo A, Soberón M, Mahillon J, Sun M, Peng D. (2020) The CRISPR-Cas systems were selectively inactivated during evolution of Bacillus cereus group for adaptation to diverse environments. ISME J. 2020 Mar 4;. doi: 10.1038/s41396-020-0623-5. 

2. Deng Y, Chen H, Li C, Xu J, Qi Q, Xu Y, Zhu Y, Zheng J, Peng D, Ruan L, Sun M. (2019) Endophyte Bacillus subtilis evade plant defense by producing lantibiotic subtilomycin to mask self-produced flagellin. Commun Biol, 2:368. 

3. Sajid M, Geng C, Li M, Wang Y, Liu H, Zheng J, Peng D, Sun M. (2018) Whole-Genome Analysis of Bacillus thuringiensis Revealing Partial Genes as a Source of Novel Cry Toxins. Appl Environ Microbiol, 84(14). doi: 10.1128/AEM.00277-18. 

4. Peng D, Luo X, Zhang N, Guo S, Zheng J, Chen L, Sun M. (2018) Small RNA-mediated Cry toxin silencing allows Bacillus thuringiensis to evade Caenorhabditis elegans avoidance behavioral defenses. Nucleic Acids Res, 46(1):159-173. 

5. Geng C, Liu Y, Li M, Tang Z, Muhammad S, Zheng J, Wan D, Peng D, Ruan L, Sun M. (2018) Dissimilar Crystal Proteins Cry5Ca1 and Cry5Da1 Synergistically Act against Meloidogyne incognita and Delay Cry5Ba-Based Nematode Resistance. Appl Environ Microbiol, 83(18). doi: 10.1128/AEM.03505-16. 

6. Zheng J, Gao Q, Liu L, Liu H, Wang Y, Peng D, Ruan L, Raymond B, Sun M. (2018) Comparative Genomics of Bacillus thuringiensis Reveals a Path to Specialized Exploitation of Multiple Invertebrate Hosts. mBio, 8(4). doi: 10.1128/mBio.00822-17. 

7. Du C, Cao S, Shi X, Nie X, Zheng J, Deng Y, Ruan L, Peng D, Sun M. (2017) Genetic and biochemical characterization of a gene operon for trans-aconitic acid, a novel nematicide from Bacillus thuringiensis. J Biol Chem, 292(8):3517-3530. 

8. Zheng J, Peng D, Chen L, Liu H, Chen F, Xu M, Ju S, Ruan L, Sun M. (2016) The Ditylenchus destructor genome provides new insights into the evolution of plant parasitic nematodes. Proc Biol Sci, 283(1835). pii: 20160942. 

9. Zhang F, Peng D, Cheng C, Zhou W, Ju S, Wan D, Yu Z, Shi J, Deng Y, Wang F, Ye X, Hu Z, Lin J, Ruan L, Sun M. (2016) Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1). PLoS Pathog, 12(1):e1005389. 

10. Peng DH, Lin J, Huang Q, Zheng W, Liu GQ, Zheng J, Zhu L, Sun M, (2016) A novel metalloproteinase virulence factor is involved in B. thuringiensis pathogenesis in nematodes and insects. Environ Microbiol, 18(3):846-862. 

11. Ju S, Lin J, Zheng J, Wang S, Zhou H, Sun M. (2016) Alcaligenes faecalis ZD02, a novel nematicidal bacterium with an extracellular serine protease virulence factor. Appl Environ Microbiol, 82(7):2112-2120. 

12. Ruan L, Crickmore N, Peng D, Sun M. (2015) Are nematodes a missing link in the confounded ecology of the entomopathogen Bacillus thuringiensis? Trends Microbiol, 23(6):341-346. 

13. Ruan L, Wang H, Cai G, Peng D, Zhou H, Zheng J, Zhu L, Wang X, Yu H, Li S, Geng C, Sun M. (2015) A two domain protein triggers heat shock pathway and necrosis pathway both in model plant and nematode. Environ Microbiol, 17(11):4547-4565. 

14. Xin B, Zheng J, Xu Z, Li C, Ruan L, Peng D, Sun M (2015) Three novel lantibiotics ticin A1, A3, and A4 have extremely stable properties and are promising food bio-preservatives. Appl Environ Microbiol, 81(20):6964-7220. 

15. Xin B, Zheng J, Xu Z, Song X, Ruan L, Peng D, Sun M. (2015) The Bacillus cereus group is an excellent reservoir of novel Lanthipeptides. Appl Environ Microbiol, 81(5):1765-1774. 

16. Zheng J, Gänzle MG, Lin XB, Ruan L, Sun M. (2015) Diversity and dynamics of bacteriocins from human microbiome. Environ Microbiol, 17(6):2133-2143. 

17. Deng Y, Li CZ, Zhu YG, Wang PX, Qi QD, Fu JJ, Peng DH, Ruan LF, Sun M. (2014) ApnI, a transmembrane protein responsible for subtilomycin immunity, unveils a novel model for lantibiotic immunity. Appl Environ Microbiol, 80(20):6303-6315.

18. Luo X, Chen L, Huang Q, Zheng J, Zhou WPeng DRuan L, Sun M. (2013) Bacillus thuringiensis metalloproteinase Bmp1 functions as a nematicidal virulence factor. Appl Environ Microbiol, 79(2):460-468.

19. Wang P, Liu Y, Zhang C, Zhu Y, Deng YGuo SPeng D, Ruan L, Sun M. (2013)The resolution and regeneration of a cointegrate plasmid reveals a model for plasmid evolution mediated by conjugation and oriT site-specific recombination. Environmental Microbiology, 15(12):3305-3318.

20. Zheng J, Peng D, Song X , Ruan L, Mahillon JSun M. (2013) Differentiation of Bacillus thuringiensis, B. cereus, and B. thuringiensis on the basis of the csaB gene reflects host source. Appl Environ Microbiol, 79(12):3860-3863.

21. Wang F, Liu Y, Zhang F, Chai L, Ruan L, Peng D, Sun M. (2012) Improvement of crystal solubility and increasing toxicity against Caenorhabditis elegans by Asparagine substitution in Block 3 of Bacillus thuringiensis crystal protein Cry5Ba. Appl Environ Microbiol, 78(20):7197-7204.

22. Ye W, Zhu L, Liu Y, Crickmore N, Peng D, Ruan L, Sun M. (2012) Mining new crystalprotein genes from Bacillus thuringiensis on the basis of mixed plasmid-enriched genome sequencing and a computational pipeline. Appl Environ Microbiol, 78(14):4795-4801.

23. Luo Y, Ruan L, Zhao C, Wang C, Peng D, Sun M. (2011) Validation of the intact Zwittermicin A biosynthetic gene cluster and discovery of a complementary resistance mechanism in Bacillus thuringiensis. Antimicrob Agents Chemother, 55(9):4161-4169.

24. Peng D, Qiu D, Ruan L, Zhou C, Sun M. (2011) Protein elicitor PemG1 from Magnaporthe grisea induces SAR in plants through the salicylic acid and Ca2+-related signaling pathways. Mol Plant Microbe Interact, 24(10):1239-1246.

25. Peng D, Wang F, Li N, Zhang Z, Song R. Zhu Z, Ruan L, Sun M. (2011) Single cysteine substitution in Bacillus thuringiensis Cry7Ba1 improves the crystal solubility and produces toxicity to Plutella xylostella larvae. Environ Microbiol, 13(10):2820-2831.

26. Liu X, Ruan L, Hu Z, Peng D, Cao S, Zheng J, Liu Y, Yu Z, Sun M. (2010) Genome wide screening revealed the genetic determinants of a antibiotic insecticide in Bacillus thuringiensis. J Biol Chem, 285: 39191-39200.

27. Fang S, Wang L, Guo W, Zhang X, Peng D, Luo C, Yu Z, Sun M. (2009) Bacillus thuringiensis Bel protein synergizes the toxicity of Cry1Ac protein to Helicoverpa armigera larvae by degrading insect intestinal mucin. Appl Environ Microbiol, 75: 5237–5243.

28. Guo S, Liu M, Peng D, Ji S, Wang P,Yu Z, Sun M. (2008) New strategy for isolating novel nematicidal crystal protein genes from Bacillus thuringiensis strain YBT-1518. Appl Environ Microbiol, 74: 6997-7001.

29. 孙明(主编),国家十五规划教材《基因工程》,2006,北京,高等教育出版社。

30. 孙明(主编),国家十五规划教材《基因工程》(第二版)2013,北京,高等教育出版社。

31. 喻子牛,邵宗泽,孙明 (主编) 中国微生物基因组研究. 2012, 北京:科学出版社。

32. (其他论文见:https://www.ncbi.nlm.nih.gov/sites/myncbi/1rcLFq9J3NKAY/bibliography/49497510/public/?sort=date&direction=descending)


备注

1. 中国微生物学会理事兼农业微生物学专业委员会副主任、湖北省暨武汉市微生物学会副理事长兼农业微生物学专业委员会主任。

2. 2000年入选教育部跨世纪优秀人才培养计划

3. 2011年入选农业部农业科研杰出人才及其创新团队

4. 2013年评为湖北省教学名师

5. 主编出版国家规划教材《基因工程》(2006第一版, 2013第二版,高等教育出版社)

6. 湖北省技术发明一等奖”(2000)1

7. 曾任国际无脊椎动物病理学会细菌专业委员会秘书长

8. 第二届国际苏云金芽胞杆菌杀虫基因命名委员会委员

9. 国家自然科学基金委员会第12届专家评审组成员

10. 第二届微生物学名词审定委员会委员

11. 农业部第六、七、八届肥料登记评审委员会委员

12. 第九届全国农药登记评审委员会委员

13. 《生物资源》期刊主编

14. 曾入选校优秀共产党员,校师德先进个人,校优秀研究生导师

 

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