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L
李博
发布人:发布时间:2020-03-16

学位:博士

职称:教授

政治面貌:中共预备党员

电话:027-87288266

邮箱:boli@mail.hzau.edu.cn

研究方向:植物先天免疫,植物与微生物互作


教育经历

2002.09-2006.06 华中农业大学,植物保护专业,学士学位

2006.09-2011.06 华中农业大学,植物病理学,博士学位


工作经历

2011.07-2011.11 华中农业大学,植物科学与技术学院,讲师

2011.12-2012.11 德州农工大学,生物化学和生物物理系,访问学者

2012.12-2015.04 德州农工大学,植物病理学和微生物学系,博士后

2015.05-2016.11 德州农工大学,植物病理学和微生物学系,助理研究员

2017.01-至今 华中农业大学,植物科学与技术学院,教授


科研成果

科研方向

通过分子生物、生物化学和遗传学等多种策略研究植物先天免疫以及植物和病原微生物互作的机理,通过遗传改良的方式提高作物对病害的抗病能力。主要科研方向包括:(1)探讨不同类型转录因子和表观遗传修饰对植物免疫基因表达调控的机制;(2)克隆鉴定番茄抗青枯病相关的免疫识别受体和功能解析,揭示其信号转导途径;(3)蛋白质翻译后修饰在植物免疫信号传导中的作用机理。

学术成绩

长期从事分子植物病理学相关研究,在Nature Communications, Nature Plants, Plant Cell, PNAS, and Current Biology等国际学术杂志上发表研究论文二十余篇,两篇论文被国际同行重点评述,在Cell Host & Microbe发表了植物PTI免疫反应基因转录调控研究进展的综述。研究发现了FLS2信号途径关闭的新机制和植物先天免疫信号途径间的交互作用,证明了RLK的酪氨酸磷酸化在动植物先天免疫反应中是保守的途径;揭示了Trihelix家族转录因子参与植物PTI免疫反应基因表达调控。


科研项目

1. 茄科劳尔氏菌劫持TGA转录因子抑制植物免疫基因表达机理的研究,国家自然科学基金面上项目(2020-2023),主持

2. Trihelix家族转录因子调控植物先天免疫的分子机理,国家自然科学基金面上项目(2018-2021),主持

3. 华中农业大学新进高层次人才科研启动项目(2017-2021),主持

4. 国家自然科学基金青年项目:核盘菌低毒相关DNA病毒1SsHADV-1)体外传播途径及控制油菜菌核病潜力研究(2013-2015),主持

5. 核盘菌低毒菌株中病毒SsHV的卫星RNA生物学功能分析,国家自然科学基金青年项目(2012-2014),参加

6. 调控核盘菌菌核形成相关miRNA的克隆及其功能研究,国家自然科学基金青年项目(2010-2013),参加

7. 精氨酸调控盾壳霉分生孢子形成途径分子机理及关键基因的克隆,国家自然科学基金面上项目(2008-2011),参加


发明专利及获奖情况

真菌病毒的发现、理论及其应用基础研究,获得湖北省自然科学奖一等奖,2018

完成人: 姜道宏、谢甲涛、程家森、付艳苹 、李博


发表论文及著作:

1. Bo Li#*, Marco Aurélio Ferreira#, Mengling Huang, Luiz Fernando Camargos, Xiao Yu, Ruan M. Teixeira, Paola A. Carpinetti, Giselle C. Mendes, Bianca C. Gouveia-Mageste, Chenglong Liu, Claudia S.L. Pontes, Otávio J.B. Brustolini, Laura G.C. Martins, Bruno P. Melo, Christiane E.M. Duarte, Libo Shan, Ping He and Elizabeth P. B. Fontes* (2019) The receptor-like kinase NIK1 targets FLS2/BAK1immune complex and inversely modulates antiviral and antibacterial immunity. Nature Communications 10:4996 

2. Bo Li#, Xiangzong Meng#, Libo Shan and Ping He* (2016) Transcriptional regulation of pattern-triggered immunity in plants. Cell Host Microbe 19(5):641-650. 

3. Marcos Oliveira#, Guangyuan Xu#, Bo Li#, Luciano Vespoli, Xiangzong Meng, Xin Chen, Xiao Yu, Suzane Ariádina de Souza, Aline C. Intorne, Abbey L. Babinat, Hisashi Koiwa, Gonçalo A. de Souza Filho, Libo Shan and Ping He* (2016) Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation. Nature Plant 15218

4. Bo Li#, Shan Jiang#, Xiao Yu, Cheng, Cheng, Shixue Chen, Yanbing Cheng, Joshua Yuan, Daohong Jiang, Ping He and Libo Shan* (2015) Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity. The Plant Cell 27: 839–856.

5. Wenwei Lin#, Bo Li#, Dongping Lu, Sixue Chen, Ning Zhu, Ping He and Libo Shan* (2014) Tyrosine phosphorylation of protein kinase complex BAK1/BIK1 mediates Arabidopsis innate immunity. Proc Natl Acad Sci USA 111 (9) 3632-363

6. Bo Li#, Dongping Lu# and Libo Shan* (2014) Ubiquitination of pattern recognition receptors in plant innate immunity. Mol Plant Pathol 15(7): 737–746. 

7. Xiao Yu#, Bo Li#, Yanping Fu, Jiatao Xie, Jiasen Cheng, Said A. Ghabrial, Guoqing Li, Xianhong Yi and Daohong Jiang* (2013) Extracellular transmission of a DNA mycovirus and its use as a natural fungicide. Proc Natl Acad Sci USA 110(4): 1452-1457

8. Xiao Yu#, Bo Li#, Yanping Fu, Daohong Jiang*, Said A. Ghabrial, Guoqing Li, Youliang Peng, Jiatao Xie, Jiasen Cheng, Junbin Huang and Xianhong Yi2010A geminivirus-related DNA mycovirus that confers hypovirulence to a plant pathogenic fungus. Proc Natl Acad Sci USA 107:8387-8392. 

9. Bo Li, Yanping Fu, Daohong Jiang*, Jiatao Xie, Jiasen Cheng, Guoqing Li, Mahammad Imran Hamid and Xianhong Yi (2010) Cyclic GMP as a second messenger in the nitric oxide mediated conidiation of the mycoparasite Coniothyrium minitans. Appl Environ Microb 76: 2830–2836.

共同作者论文: 

10. Xiao Yu#, Guangyuan Xu#, Bo Li, Luciano de Souza Vespoli, Hai Liu, Wolfgang Moeder, Sixue Chen, Marcos V.V. de Oliveira, Suzane Aria´dina de Souza, Wenyong Shao, Ba´rbara Rodrigues, Yi Ma, Shweta Chhajed, Shaowu Xue, Gerald A. Berkowitz, Keiko Yoshioka, Ping He* and Libo Shan* (2019) The receptor kinases BAK1/SERK4 regulate Ca2+ channel-mediated cellular homeostasis for cell death containment. Current Biology 29, 1–13

11. Xiao Yu, Bo Li, Geng-Jen Jang, Shan Jiang,1 Daohong Jiang,3 Jyan-Chyun Jang, Shu-Hsing Wu, Libo Shan, and Ping He (2019) Orchestration of processing body dynamics and mRNA decay in Arabidopsis immunity. Cell Reports 28, 2194–2205

12. Feng Ding, Jiasen Cheng, Yanping Fu, Tao Chen, Bo Li, Daohong Jiang and Jiatao Xie (2019) Early transcriptional response to DNA virus infection in Sclerotinia sclerotiorum. Viruses 11:278

13. Cheng Xiong, Dan Luo, Aihua Lin, Chunli Zhang, Libo Shan, Ping He, Bo Li, Qiaomei Zhang,Bin Hua, Zilv Yuan, Hanxia Li, Junhong Zhang, Changxian Yang, Yongen Lu, Zhibiao Ye and Taotao Wang. (2019) A tomato B-box protein SlBBX20 modulates carotenoid biosynthesis by directly activating PHYTOENE SYNTHASE 1, and is targeted for 26S proteasome-mediated degradation New Phytologist 221: 279–294

14. Feng Yi Cao, Thomas A. DeFalco, Wolfgang Moeder, Bo Li, Yunchen Gong, Xiao-Min Liu, Masatoshi Taniguchi, Shelley Lumba, Shigeo Toh, Libo Shan, Brian Ellis, Darrell Desveaux and Keiko Yoshioka (2018) Arabidopsis ETHYLENE RESPONSE FACTOR 8 (ERF8) has dual functions in ABA signaling and immunity. BMC Plant Biology 18:211

15. Hongchang Ran, Lijiang Liu, Bo Li, Jiasen Cheng, Yanping Fu, Daohong Jiang, and Jiatao Xie. (2016) Co-infection of a hypovirulent isolate of Sclerotinia sclerotiorum with a new botybirnavirus and a strain of a mitovirus. Virology Journal 13:92

16. Si Liu, Jiatao Xie, Jiasen Cheng, Bo Li, Tao Chen, Yanping Fu, Guoqing Li, Manqun Wang, Huanan Jin, Hu Wan, and Daohong Jiang*.2016 Fungal DNA virus infects a mycophagous insect and utilizes it as a transmission vector. Proc Natl Acad Sci USA. 2016.113(45)12803-12808

17. Xiangzong Meng, Jinggeng Zhou, Jiao Tang, Bo Li, Marcos V. V. de Oliveira, Jijie Chai, Ping He and Libo Shan* (2016) Ligand-induced receptor-like kinase complex regulates floral organ abscission in Arabidopsis. Cell Reports 14(6): 1330-1338.(IF=8.358)

18. Baomin Feng, Chenglong Liu, Marcos Oliveira, Aline C. Intorne, Bo Li, Kevin Babilonia, Gonçalo A. de Souza Filho, Libo Shan and Ping He* (2015) Protein poly(ADP-ribosyl)ation regulates Arabidopsis immune gene expression and defense responses. PLOS Genetics 11(1): e1004936. doi:10.1371/journal. pgen. 1004936.(IF=7.528)

19. Fangjun Li#, Cheng Cheng#, Fuhao Cui#, Marcos V.V. de Oliveira#, Xiao Yu, Xiangzong Meng, Aline C. Intorne, Kevin Babilonia, Maoying Li, Bo Li, Sixue Chen, Xianfeng Ma, Shunyuan Xiao, Yi Zheng, Zhangjun Fei, Richard P. Metz, Charles D. Johnson, Hisashi Koiwa, Wenxian Sun, Zhaohu Li, Gonçalo A. de Souza Filho, Libo Shan* and Ping He* (2014) Modulation of RNA Polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity. Cell Host Microbe 16(6): 2014 748–758. (IF=12.328)

20. Wei Wei, Wenjun Zhu, Jiasen Cheng, Jiatao Xie, Bo Li, Daohong Jiang, Guoqing Li, Xianhong Yi and Yanping Fu* (2013) CmPEX6, a Gene involved in peroxisome biogenesis, is essential for parasitism and conidiation by the sclerotial parasite Coniothyrium. minitans. Appl Environ Microb 79 (12): 3658 –36667. (IF=3.668)

21. Jiahong Zhou, Yanping Fu, Jiatao Xie, Bo Li, Daohong Jiang, Guoqing Li and Jiasen Cheng* (2012) Identification of microRNA-like RNAs in a plant pathogenic fungus Sclerotinia sclerotiorum by high-throughput sequencing. Mol Genet Genomics 287:275–282. (IF=2.728) 

22. Huiquan Liu, Yanping Fu, Bo Li, Xiao Yu, Jiatao Xie, Jiasen Cheng, Said A Ghabrial, Guoqing Li, Xianhong Yi and Daohong Jiang* (2011) Widespread Horizontal Gene Transfer from Circular Single-stranded DNA Viruses to Eukaryotic Genomes. BMC Evol Biol 11:276 (IF=3.368)

23. Jiatao Xie, Yanping Fu, Daohong Jiang*, Guoqing Li, Junbin Huang, Bo Li, Tom Hsiang and Youliang Peng (2008) Intergeneric transfer of ribosomal genes between two fungi. BMC Evol Biol 8:87 (IF=3.368)


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