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H
何璟
发布人:发布时间:2020-09-09


职称 教授

学位 博士

邮箱 hejingjj@mail.hzau.edu.cn

研究方向 链霉菌次级代谢合成、调控及抗性机制


教育经历

1995-1999 华中农业大学 生命科学技术学院 生物技术专业 理学学士学位

1998-2001 华中农业大学 生命科学技术学院 生物化学与分子生物学专业 理学硕士学位

2001-2005 Friedrich-Schiller-Universität Jena(德国耶拿大学) Hans-Knoll-Institute for Natural Products Research(天然产物研究所)理学博士学位



主要职历

2005-2007 Rheinische Friedrich-Wilhelms-Universität Bonn(德国波恩大学)Kekulé Institute of Organic Chemistry and Biochemistry(有机化学和生物化学研究所) 博士后

2007-2008 University of Chicago(美国芝加哥大学)Department of Chemistry(化学系)博士后

2008-至今 华中农业大学 生命科学技术学院 教授


代表性学术论文

1. Ying Zhai, Silei Bai, Jingjing Liu, Liyuan Yang, Li Han, Xueshi Huang, Jing He*. Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway. Biochem Biophys Res Commun. 2016, 473(1):329-335.

2. Shan Wang, Kai Liu, Le Xiao, LiYuan Yang, Hong Li, FeiXue Zhang, Lei Lei, ShengQing Li, Xu Feng, AiYing Li, Jing He*. Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage. Nucleic Acids Res. 2016, 44(1):187-197.

3. Jin Lu, Qiang He, Luyao Huang, Xiaofeng Cai, Wenwen Guo, Jing He, Lili Zhang, Aiying Li*. Accumulation of a bioactive benzoisochromanequinone compound kalafungin by wild type antitumor-medermycin-producing streptomycete strain. PLos One. 2015, 10(2):e0117690.

4. Benjamin Busch, Nico Ueberschaar, Swantje Behnken, Yuki Sugimoto, Martina Werneburg, Nelly Traitcheva, Jing He, Christian Hertweck. Multifactorial control of iteration events in a modular polyketide assembly line. Angew Chem Int Ed Engl. 2013, 52(20):5285-5289.

5. Shan Wang, Ruifang Zhao, Kai Liu, Mengyi Zhu, Aiying Li, Jing He*. Essential role of an unknown gene aziU3 in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems for Streptomyces sahachiroi. FEMS Microbiol Lett. 2012, 337(2):147-154.

6. Sheng Huang, Yudong Zhao,Zhiwei Qin, Xiaoling Wang, Mayca Onega, Li Chen, Jing He*, Yi Yu*, Hai Deng*. Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus. Process Biochemistry. 2011, 46(3):811-816.

7. Martina Werneburg, Benjamin Busch, Jing He, Martin E.A. Richter, Longkuan Xiang, Bradley S. Moore, Martin Roth, Hans-Martin Dahse, Christian Hertweck. Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. J Am Chem Soc. 2010, 132(30):10407-10413.

8. Keya Zhang, Jing He, Min Yang, Jun Yin. Identifying natural product biosynthetic genes from a soil metagenome by using T7 phage selection. Chembiochem. 2009, 10(16):2599-2606.

9. Nelly Traitcheva, Holger Jenke-Kodama, Jing He, Elke Dittmann and Christian Hertweck. Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective. Chembiochem. 2007, 8(15):1841-1849.

10. Markus Muller, Jing He, Christian Hertweck. Dissection of the late steps in aureothin biosynthesis. Chembiochem. 2006, 7(1):37-39.

11. Jing He and Christian Hertweck. Functional Analysis of the Aureothin Iterative Type I Polyketide Synthase. ChembioChem. 2005, 6(5):908-912.

12. Martina Ziehl, Jing He, H.-M. Dahse and Christian Hertweck. Mutasynthesis of Aureonitrile, an Aureothin Derivative with Significant Cytostatic Effect. Angewandte Chemie, Chem. Int. Ed. Engl. 2005, 44(8):1202-1205.

13. Jing He, Markus Müller and Christian Hertweck. Formation of the Aureothin Tetrahydrofuran Ring by a Bifunctional Cytochrome P450 Monooxygenase. J. Am. Chem. Soc. 2004, 126(51):16742-16743.

14. Jing He and Christian Hertweck. Biosynthetic Origin of the Rare Nitro Aryl Moiety of the Polyketide Antibiotic Aureothin: Discovery of an Unprecedented N-Oxygenase. J. Am. Chem. Soc. 2004, 126(12):3694-3695.

15. Jing He and Christian Hertweck. Iteration as Programmed Event during Polyketide Assembly; Molecular Analysis of the Aureothin Biosynthesis Gene Cluster. Chem. Biol. 2003, 10(12):1225-1232.

16. Shi Chen, Xi Huang, Xiufen Zhou, Linquan Bai, Jing He, Ki Jun Jeong, Sang Yup Lee, and Zixin Deng. Organizational and Mutational Analysis of a Complete FR-008/ Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex. Chem. Biol. 2003, 10(11):1065-1076.



授权发明专利

1. 何璟,王珊,一种阿嗪霉素B的基因工程菌WSD2CP及制备方法和应用,2013,中国,专利号ZL 201210110348.7。

2. 何璟,朱梦奕,赵瑞芳,王利娟,硫藤黄链霉菌抗生素调控基因及提高链霉菌抗生素产量的方法,2013,中国,专利号ZL 201310177365.7。

3. Christian Hertweck,Jing He,“Amino-Oxidase” from Streptomyces thioluteus. 2003,欧洲,专利号10335447.6。

4. Christian Hertweck, Martina Ziehl, Jing He, H.-M. Dahse,“HKI 10429005, neue zytostatische Wirkstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung”,2004,欧洲,专利号102004040014.8。


获得奖励

2009年入选教育部新世纪优秀人才支持计划

2004年获国家优秀自费留学生奖学金




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